首页 | 本学科首页   官方微博 | 高级检索  
     


The interaction between growth hormone and the thyroid axis in hypopituitary patients
Authors:Lucy Ann Behan  John P. Monson  Amar Agha
Affiliation:1. Academic Departments of Endocrinology, Beaumont Hospital, Dublin, Ireland;2. St Bartholomew’s Hospital, London, England
Abstract:Alterations in the hypothalamo‐pituitary‐thyroid axis have been reported following growth hormone (GH) administration in both adults and children with and without growth hormone deficiency. Reductions in serum free thyroxine (T4), increased tri‐iodothyronine (T3) with or without a reduction in serum thyroid‐stimulating hormone secretion have been reported following GH replacement, but there are wide inconsistencies in the literature about these perturbations. The clinical significance of these changes in thyroid function remains uncertain. Some authors report the changes are transient and revert to normal after a few months or longer. However, in adult hypopituitary patients, GH replacement has been reported to unmask central hypothyroidism biochemically in 36–47% of apparently euthyroid patients, necessitating thyroxine replacement and resulting in an attenuation of the benefit of GH replacement on quality of life in those who became biochemically hypothyroid after GH replacement. The group at highest risk are those with organic pituitary disease or multiple pituitary hormone deficiencies. It is therefore prudent to monitor thyroid function in hypopituitary patients starting GH therapy to identify those who will develop clinical and biochemical features of central hypothyroidism, thus facilitating optimal and timely replacement.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号