| 磷酸肌酸对儿童柯萨奇病毒性心肌炎的保护作用 |
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| 引用本文： | 李军,李鸿珠,李萍,郭津,王丽岩,徐长庆.磷酸肌酸对儿童柯萨奇病毒性心肌炎的保护作用[J].实用儿科临床杂志,2010(6). |
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| 作者姓名： | 李军 李鸿珠 李萍 郭津 王丽岩 徐长庆 |
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| 作者单位： | 哈尔滨市儿童医院小儿心血管内科;哈尔滨医科大学病理生理教研室;哈尔滨市儿童医院检验科;哈尔滨市儿童医院心电室; |
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| 基金项目： | 黑龙江省科学技术计划项目(WC02303) |
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| 摘 要： | 目的观察磷酸肌酸(CP)对儿童柯萨奇病毒心肌炎(CVM)的保护作用,并初步探讨其可能机制。方法选取40例柯萨奇B组病毒感染心肌炎患儿为CVM组,并随机分为CP治疗组(CP组)和1,6-二磷酸果糖治疗组(果糖组),每组20例。同时,选择体检正常的健康儿童20例作为健康对照组。观察指标主要包括:血清柯萨奇病毒RNA和抗体IgM、心肌酶、高敏C反应蛋白(hs-CRP)、丙二醛(MDA)/超氧化物歧化酶(SOD)和细胞凋亡因子sFas/sFasL。MDA测定采用硫代巴比妥法,SOD测定采用化学比色法,sFas和sFasL测定采用双抗体夹心ABC-ELISA法;AST、LDH、α-羟丁酸脱氢酶(HBDH)、CK和CK-MB等心肌酶均由本院检验科采用全自动生化分析仪测定。应用SPSS13.0软件进行统计学分析。结果与健康对照组比较,CVM组血清柯萨奇病毒RNA和抗体IgM均显著增高,心肌酶、hs-CRP、MDA、sFas/sFasL显著升高(Pa<0.05,0.01),SOD明显降低(P<0.01);与治疗前比较,CP组及果糖组治疗后心肌酶(除果糖组CK外)、hs-CRP、MDA、sFas和sFasL各指标均显著下降(P...
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| 关 键 词： | 磷酸肌酸 柯萨奇病毒心肌炎 氧自由基 凋亡 儿童 |
Protective Effect of Creatine Phosphate for Coxsachievirus Myocarditis in Children |
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| LI Jun,LI Hong-zhu,LI Ping,GUO Jin,WANG Li-yan,XU Chang-qing.Protective Effect of Creatine Phosphate for Coxsachievirus Myocarditis in Children[J].Journal of Applied Clinical Pediatrics,2010(6). |
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| Authors: | LI Jun LI Hong-zhu LI Ping GUO Jin WANG Li-yan XU Chang-qing |
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| Institution: | LI Jun1,LI Hong-zhu2,LI Ping3,GUO Jin2,WANG Li-yan4,XU Chang-qing2(1.Department of Pediatric Cardiovascular,Harbin Children\'s Hospital,Harbin 150010,Heilongjiang Province,China,2.Department of Pathophysiology,Harbin Medical University,Harbin 150086,3.Department of Clinical Laboratory,4.Department of Electrocardiogram,China) |
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| Abstract: | Objective To observe the protective effect of creatine phosphate(CP)for coxsachievirus myocarditis(CVM)in children,and explore its mechanisms.Methods Forty children with coxsachievirus B myocarditis were selected(CVM group)and were randomly divided into CP group(n=20)and fructose group(n=20).Meanwhile,20 healthy children were selected as control group.Serum coxsachievirus RNA and antibody IgM,myocardial enzymes,high-sensitivity C reactive protein(hs-CRP),malonaldehye(MDA)/superoxide dismutise(SOD),apoptosis... |
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| Keywords: | creatine phosphate coxsackievirus myocarditis oxygen free radical apoptosis child |
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