High serum procalcitonin levels in patients with periodontitis and chronic migraine |
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| Authors: | Yago Leira Pablo Ameijeira Clara Domínguez Rogelio Leira Juan Blanco |
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| Institution: | 1. Periodontology Unit, Faculty of Medicine and Odontology, University of Santiago de Compostela, Spain;2. Odontología Médico‐Quirúrgica (OMEQUI) Research Group, Health Research Institute of Santiago de Compostela (IDIS), Spain;3. Service of Neurology, Headache Unit, Hospital Clínico Universitario, University of Santiago de Compostela, Spain |
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| Abstract: | 1 Background To evaluate the contribution of chronic periodontitis (CP) to serum procalcitonin (proCT) levels in chronic migraine (CM) patients in a cross‐sectional study. 2 Methods We included 138 subjects divided into 4 groups based on clinical features of CM and periodontal parameters: systemically and periodontally healthy individuals (n = 37), systemically healthy and CP patients (n = 19), CM and periodontally healthy patients (n = 34), and CM+CP patients (n = 48). Demographic, neurological, clinical data as well as full‐mouth periodontal records were obtained. ProCT and high sensitive C‐reactive protein (hs‐CRP) serum levels were determined from blood samples taken during migraine interictal period. 3 Results Patients from the CP+CM group (0.056±0.006 ng/mL) had significantly higher serum proCT levels in comparison with the systemically and periodontally healthy group (0.029±0.019 ng/mL), CM group (0.041±0.002 ng/mL), or CP group (0.034±0.014 ng/mL) (p < 0.001). There were no significant differences in hs‐CRP between groups (p = 0.081). Multiple linear regression analysis showed that CP was associated with increased proCT levels in CM patients (R2 = 0.293, p < 0.001). 4 Conclusions CP independently contributes to elevated serum proCT levels in CM patients. These findings suggest that CP could play a role in migraine chronification. |
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| Keywords: | headache inflammation migraine periodontitis procalcitonin |
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