胆管癌三维适形放射治疗疗效观察

目的 观察三维适形放射治疗胆管癌的疗效。方法 用三维适形放射治疗方法治疗胆管癌21例，观察疗效和并发症。结果 肿瘤局部控制率为52．38％(11/21)。1、2、3年生存率分别是42．85％(9／21)、28．57％(6/21)、14．29％(3／21)。中位生存期16.5个月(2～38个月)。放疗后晚期，8例患者出现十二指肠溃疡，4例死于上消化道出血。结论 三维适形放射治疗胆管癌可以达到姑息治疗的目的，控制放疗后并发症的发生是提高患者生存率的关键。

Therapeutic effect of three-dimensional conformal radiotherapy on hilar cholangiocarcinoma]

OBJECTIVE: To evaluate the therapeutic effects of three-dimensional conformal radiotherapy (3D-CRT) for hilar cholangiocarcinoma. METHODS: Twenty-one patients with unresectable hilar cholangiocarcinoma were treated with 3D-CRT and the acute effects and survival rates were observed. RESULTS: Eleven (52.38%) of the 21 patients achieved a complete or partial remission. One, 2- and 3-year overall survival rates were 42.85% (9/21), 28.57% (6/21), and 14.29% (3/21), respectively, with a median overall survival rate of 16.5 months. Eight patients developed duodenal ulcer as a late complication of radiotherapy, and 4 patients died of gastrointestinal bleeding. CONCLUSIONS: 3D-CRT can be considered as a valuable palliative approach for unresectabe hilar cholangiocarcinoma, and effective management of the late complications of radiotherapy play a key role in increasing survival rates of the patients.