序贯疗法治疗幽门螺杆菌阳性肝源性溃疡的疗效观察

目的:观察由雷贝拉唑联合阿莫西林、克拉霉素、替硝唑组成的10 d序贯疗法对幽门螺杆菌(HP)阳性肝源性溃疡的疗效.方法:68例HP阳性肝源性溃疡患者随机分为研究组(n=30)和对照组(n=38),研究组采用序贯疗法,前5d雷贝拉唑+阿莫西林,后5 d雷贝拉唑+克拉霉素和替硝唑,再给予雷贝拉唑治疗18 d;对照组三联疗法为雷贝拉唑+阿莫西林+克拉霉素共7d,再给予雷贝拉唑治疗21d.结果:研究组和对照组的溃疡愈合率分别为73.3%和63.2%,无统计学差异(P>0.05);研究组HP根除率90%明显高于对照组的68.4%(P<0.05).结论:序贯治疗HP阳性肝源性溃疡HP根除率较经典疗法高.

Curative Efficacy of the Sequential Therapy for Hepatogeuic Ulcer with Helicobacter Pylori Infection

Objective： To investigate the curative efficacy of 10 days sequential therapy （including rabeprazole, amoxicillin, clarithromycin and tinidazole ） for hepatogenic ulcer with Helicobacter pylori （HP） infection. Methods ： 68 patients with HP positive hepatogenic ulcer were randomly divided into research group and control group. 30 cases in research group received 10 days sequential therapy （rabeprazole plus amoxicillin for the first 5 days, followed by rabeprazole, clarithromycin and tinidazole for another 5 days） and 18 days rabeprazole therapy, 38 cases in control group received standard 7 days therapy （rabeprazole plus amoxicillin and clarithromycin for 7days） and 21 days rabeprazole therapy. Results： Ulcer healing rates were 73.3% and 63.2% respectively in research group and control group. The ulcer healing rate was no significant difference between the two groups （P〉0.05）. HP eradication rate was significant higher in research group （90%） than that in control group （68.4%） （P〈0.05）. Conclusion： Sequential therapy can achieve higher HP eradication rate in hepatogenic ulcer patients compared to standard therapy.