Antiplasmodial constituents from the fruit pericarp of Pentadesma butyracea |
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Authors: | Lenta Bruno Ndjakou Kamdem Louis Marie Ngouela Silvère Tantangmo Ferdinand Devkota Krishna Prasad Boyom Fabrice Fekam Rosenthal Philip John Tsamo Etienne |
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Institution: | Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon. |
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Abstract: | Bioassay-guided fractionation of the fruit pericarp of Pentadesma butyracea, using the antiplasmodial test, led to the isolation of a new xanthone, named pentadexanthone (1), together with six known compounds: cratoxylone (2), α-mangostin (3), 1,3,5-trihydroxy-2-methoxyxanthone (4), garcinone E (5), (-)-epicathechin (6), and lupeol (7). The structure of 1 was elucidated by spectroscopic data analysis. An antiplasmodial assay was performed with the isolates, in which compounds 1- 3 and 5 exhibited potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC?? values below 3 μM. |
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