| 利福喷丁的临床药物动力学研究 |
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| 引用本文： | 张菁 曹忆堇. 利福喷丁的临床药物动力学研究[J]. 中国抗生素杂志, 1994, 19(6): 456-458 |
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| 作者姓名： | 张菁 曹忆堇 |
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| 作者单位： | 上海医科大学华山医院抗生素研究所 |
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| 摘 要： | 本文报道利福喷丁正常人药物动力学研究结果，健康志愿者１０人单剂口服利福喷丁粉剂及胶囊６００ｍｇ后的体内过程均符合血管外一室模型，其血药峰浓度分别为１７．４３ｍｇ／Ｌ（粉剂）和１８．３８ｍｇ／Ｌ（胶囊），达峰时间为９，７０ｈ（粉剂和）和８．２１ｈ（胶囊），消除半衰期（ｔ１／２ｋｅ）为１９．９０ｈ（粉剂）和１９．４２ｈ（胶囊），以上各项参数经统计学处理均无明显意义，胶囊的相对生物利用度为１０４．７２％，口服该药后有少量自尿中以原形排出体外，给药后２ｈ内分别排出给药量的１１．３０％（粉剂）和１１，２９％（胶囊）。
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| 关 键 词： | 利福喷丁；药物动力学 |
CLINICAL PHARMACOKINETIC STUDY ON RTFAPENTINE |
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| Zhang Qing, Cao Yijin,Zhang Yingyuan. CLINICAL PHARMACOKINETIC STUDY ON RTFAPENTINE[J]. Chinese Journal of Antibiotics, 1994, 19(6): 456-458 |
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| Authors: | Zhang Qing Cao Yijin Zhang Yingyuan |
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| Abstract: | Pharmacokinetic study on Rifapentine was carried out in normal volunteers.Oral administration of 600mg Rifapentine in pow-der and capsule form was fitted to one-compartment model,Mean peak serum concentratlon of powder and capsule was17.43mg/L and 18.38mg/Lrespcctively. The time to peak serum concentration was 9.70h for powder and 8.21h for capsule.The serum elimination half-life was 19.9h for polvder and 19.42h for capsule.Difference of the above parameters was not statistically significant.The relative bioavaillity of Rifapcntine capsuie was 104.72%.Small amount of Rifapentine was excreted uncha-nged in urine. The urinary recovery rate of Rifapentine over 72hwas 11.9%for powder and 11.20%for capsule. |
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| Keywords: | Rifapentine Pharmacokinetic |
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