| 免疫抑制剂I2190B的分离与鉴别 |
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| 引用本文： | 金莲舫,姚军.免疫抑制剂I2190B的分离与鉴别[J].中国抗生素杂志,1994,19(5):323-327. |
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| 作者姓名： | 金莲舫 姚军 |
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| 作者单位： | 中国医学科学院医药生物技术研究所 |
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| 基金项目： | 卫生部和国家自然科学基金 |
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| 摘 要： | 在筛选免疫抑制剂的过程中，找到了一株吸水类链霉菌Ｉ２１９０，属于ＦＫ－５０６类化合物的产生菌，从其发酵产物中已分离出Ａ、Ｂ二个组份，基于光谱数据和理化特性的分析，证实１２１９０Ｂ和免疫抑制剂ＦＫ－５２０及ＬＤ－６８３５９０（Ｉｍｍｕｎｏｍｙｃｉｎ）均为同一物质。
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| 关 键 词： | 免疫抑制剂 分离 鉴别 FK－520 L－683590 I2190B |
I2190B,AN IMMUNOSUPPRESSANT,ISOLATION AND IDENTIFICATION |
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| Jin Lianfang,Yao Jun,Zhao Chunyan,Gao Ping,Li Siying.I2190B,AN IMMUNOSUPPRESSANT,ISOLATION AND IDENTIFICATION[J].Chinese Journal of Antibiotics,1994,19(5):323-327. |
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| Authors: | Jin Lianfang Yao Jun Zhao Chunyan Gao Ping Li Siying |
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| Abstract: | In the course of screening immunosuppressant,we isola-ted a SfrepfomyceS hygroscopicus No,2190-producing the series cotnpounds of FK-506,Two components were isolated from the mycelium of culture broth.One of them,I2190B showed very strong inhibitory effect on lym-phocyte proliferation and IL-2production.Based on the spectral data and physical-chemical properties of I2190B,It has been identified as FK-520 and L-683590(immunomycin). |
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| Keywords: | Immunosuppressant Isolation IdeIltification FK-520 L-683590 I2190B |
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