| 庆大霉素耐药质粒的检测及P1Gm噬菌体的分离 |
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| 引用本文： | 薛胜平,包幼迪.庆大霉素耐药质粒的检测及P1Gm噬菌体的分离[J].中国抗生素杂志,1994,19(4):308-312. |
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| 作者姓名： | 薛胜平 包幼迪 |
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| 作者单位： | 华北制药厂，福建医学院基因工程研究室 |
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| 摘 要： | 本文检测邯郸、福州两地１４９株新生儿胎便中肠道杆菌的耐药率、ＭＩＣ、耐药质位及其消除率。结果表明庆大霉素（Ｇｍ）耐药基因主要位于耐药质粒上；Ｇｍ耐药质粒较稳定、宿主范围较广。此外，本文获得８株ＰＩＣｍｃｌ（ｔｓ）１００与Ｇｍ耐药质粒形成的类似于Ｐ１Ｃｍ性质而由Ｇｍ取代Ｃｍ基因的Ｐ１Ｇｍｃｌ（ｔｓ）１００。Ｐ１Ｃｍ或Ｐ１Ｇｍ可感染９种肠道杆菌。
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| 关 键 词： | 庆大霉素 庆大霉素耐药质粒 噬菌体 |
DETECTION OF GENTAMICIN RESIS TANT PLASMID,Gmr AND THE ISOLATION OF PlGm PHAGES |
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| Xue Sengping.DETECTION OF GENTAMICIN RESIS TANT PLASMID,Gmr AND THE ISOLATION OF PlGm PHAGES[J].Chinese Journal of Antibiotics,1994,19(4):308-312. |
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| Authors: | Xue Sengping |
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| Abstract: | strains of enterobacteria were isolated from the fetalstools in two cities of China, Fuzhou and Handan. Following data weredetected and compared between two groups/cities of bacteria:1.MICand resistant rates to nine antibiotics;2.Resistant plasmids and their curingrates. Major Gm resistant genes are located at plasmids which are stableand have wide hosts. In addition, 8 PlGm were obtained.PIGm has sitm-ilar property to PlCm. It is persumed Gm gene replaces Cm resistant geneby means of/through recombination exchange between their ISI sequences.PIGm and PlCm can infect nine kinds of enterobacteria. |
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| Keywords: | Gentamicin Gentamicin resistant plasrnid Phage |
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