PIK3CA alterations in Middle Eastern ovarian cancers |
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| Authors: | Jehad Abubaker Prashant Bavi Wael Al-Haqawi Zeenath Jehan Adnan Munkarah Shahab Uddin Khawla S Al-Kuraya |
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| Affiliation: | (1) Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia;(2) Department of Obstetrics and Gynecology, King Faisal Specialist Hospital and Research Center, Riyadh, PO Box 3354, 11211 Riyadh, Saudi Arabia |
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| Abstract: | Background PI3K/AKTsignaling pathway plays an important role in cell growth, proliferation, and tumorgenesis of various malignancies. This signaling pathway has been shown to be frequently altered in several human cancers including ovarian cancers. However the role of this oncogenic signaling pathway has not been explored in the Middle Eastern epithelial ovarian cancer (EOC). Therefore, we investigated PI3K/AKT genetic alterations such as PIK3CA amplification, PIK3CA mutation, PTEN protein loss and their relationships with various clinicopathological characteristics in 156 EOCs. |
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