| 通痹灵对佐剂性关节炎大鼠滑膜细胞MCP-1 mRNA表达的影响 |
| |
| 引用本文： | 熊茂林,宋畅,林敬明,宋烈昌.通痹灵对佐剂性关节炎大鼠滑膜细胞MCP-1 mRNA表达的影响[J].中药材,2002,25(10):722-724. |
| |
| 作者姓名： | 熊茂林 宋畅 林敬明 宋烈昌 |
| |
| 作者单位： | 1. 中山大学中山医学院,广州,510080
2. 第一军医大学珠江医院,广州,510515 |
| |
| 摘 要： | 目的:探讨中药复方制剂通痹灵(以桂枝芍药知母汤为基础)对佐剂性关节炎大鼠滑膜细胞单核细胞趋化蛋白 1(MCP-1)mRNA表达的影响。方法:采用半定量RT-PCR法测定佐剂性关节炎大鼠滑膜细胞MCP-1 mRNA表达水平。结果:通痹灵明显抑制了佐剂性关节炎大鼠滑膜细胞MCP-1 mRNA的表达,提示通痹灵治疗类风湿性关节炎的分子机制与抑制MCP-1基因表达有关。
|
| 关 键 词： | 通痹灵 佐剂性关节炎 MCP-1 mRNA RT-PCR |
| 修稿时间： | 2002年6月21日 |
Effect of Tongbiling on the Expression of MCP-1 mRNA of Synovial Cells in Rats with Adjuvant Arthritis |
| |
| Xiong Maolin,Song Chang.Effect of Tongbiling on the Expression of MCP-1 mRNA of Synovial Cells in Rats with Adjuvant Arthritis[J].Jorunal of Chinese Medicinal Materials,2002,25(10):722-724. |
| |
| Authors: | Xiong Maolin Song Chang |
| |
| Institution: | Sun Yat-sen Medical College, Sun Yat-sen University, Guangzhou 510080. |
| |
| Abstract: | Objective: To study the effect of Tongbiling, a complex preparation of Chinese traditional medicine, on the expression of MCP-1 mRNA of synovial ecus in rats with adjuvant arthritis. Method: The expression level of MCP-1 mRNA in synoviocytes from rats with adjuvant arthritis was assayed by the method of RT-PCR. Result: The amounts of MCP-1 mRNA expression in synoviocytes from rats with adjuvant arthritis were distinctly decreased by Tongbiling. It suggested that Tongbiling had inhibition effect on rheumatoid arthritis by a down regulation for the expression of MCP-1 mRNA in the inflamed synoviocytes. |
| |
| Keywords: | Adjuvant arthritis MCP-1 mRNA RT-PCR |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
