Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents |
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| Authors: | Ammini Chandramohan V Fernandez-Canon Jose Shroads Albert L Cornett Rachel Cheung Jang James Margaret O Henderson George N Grompe Markus Stacpoole Peter W |
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| Affiliation: | Division of Endocrinology and Metabolism, Department of Medicine, University of Florida, Gainesville, FL 32610, USA. |
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| Abstract: | |
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| Keywords: | DCA, dichloroacetate MAAI, maleylacetoacetate isomerase SD, Sprague-Dawley mRNA, messenger ribonucleic acid MAAI-KO, maleylacetoacetate isomerase knockout SA, succinylacetone δ-ALA, delta-aminolevulinate CLA, congenital lactic acidosis PDH, pyruvate dehydrogenase GSTZ1, glutathione transferase zeta 1 MA, maleylacetone HMG-CoA, β-hydroxy-β-methylglutaryl-CoA NMR, nuclear magnetic resonance PVDF, polyvinylidene fluoride SSC, selenosemicarbazide GC-MS, gas chromatography-mass spectrometry SIM, selective ion monitoring MCA, monochloroacetic acid FA, fumarylacetone MAA, maleylacetoacetate FAA, fumarylacetoacetate |
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