阿片δ受体在胎兔窘迫中作用的实验研究

目的　探讨δ受体在胎兔窘迫中的作用。方法　将 16只孕 30d母免随机分为 4组 (每组 4只 ) :正常妊娠组 (对照组 )、胎兔窘迫未治疗组 (胎窘组 )、胎兔窘迫生理盐水治疗组 (盐水组 ) ,胎兔窘迫ICI174864治疗组 (ICI组 ) ;后 2组母兔窒息前分别静脉注入生理盐水及δ受体拮抗剂ICI174864。胎兔均于剖宫产后 1、5、10、15、30min进行呼吸、心跳、肤色、肌张力、反射评分。结果　ICI组胎兔Apgar评分显著高于胎窘组及盐水组 (P <0 .0 5及P <0 .0 1) ,后二者间无差异 (P >0 .0 5 )。结论　内源性阿片肽通过δ受体的介导参与胎儿窘迫过程。

Experimental study on the role of the delta- receptor in fetal distress

Objective: To study the role of the delta-receptor in fatal distress. Methods: Pregnant near-term rabbits were given an intravenous dose of saline or the opiate antagonist ICI and then asphyxiated. The rabbit fetuses were delivered by cesarean section and evaluated for respiration, heart beat, color,muscle tone, and response to stimulation at 1,5,10,15,and 30 minutes of age. Results: The ICI-treated pups had significantly better scores than the saline-treated pups and the fetal distress group(P<0.05); there was no statistical difference between the saline group and the no treated pups (P>0.05).Conclusions: These results suggested that delta-receptor participated in conducting the endogenous opioid peptides effect, it was associated with the pathophysiological changes in fetal distress.