Influence of transjugular intrahepatic portosystemic shunts (TIPS) on tissue oxygenation in patients with cirrhosis |
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Authors: | C cile Deni ,Florence Vachi ry,Adrian Gadano,Philippe Sogni,Annie Elman,Richard Moreau,Dominique Valla,Didier Lebrec |
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Affiliation: | Cécile Denié,Florence Vachiéry,Adrian Gadano,Philippe Sogni,Annie Elman,Richard Moreau,Dominique Valla,Didier Lebrec |
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Abstract: | ABSTRACT— Aims/Backgrounds: The aim of this prospective study was to evaluate the influence of transjugular portosystemic intrahepatic shunts (TIPS) on tissue oxygenation in patients with cirrhosis and refractory ascites. Methods: Five shunted patients were included in the study. The blood and tissue oxygenation values were analyzed 12 days and 4 months after TIPS procedure. The results were compared with those observed in patients treated by paracentesis. Results: Unlike patients treated by paracentesis, PaO2 values remained unchanged throughout follow-up in shunted patients. After the TIPS procedure, there was a transient increase in systemic O2 transport and O2 uptake and a transient decrease in O2 saturation of hepatic oxyhemoglobin. After 4 months, TIPS resulted in an increase in PCO2 values and bicarbonate concentrations. Conclusions: The TIPS procedure seems to prevent the decrease in PaO2 observed in patients treated by paracentesis and may improve the respiratory alkalosis of cirrhosis. |
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Keywords: | ascites cirrhosis hypoxemia intrahepatic portosystemic shunt |
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