高血压病患者vWF检测的临床意义

目的探讨血管性假血友病因子(vWF)检测在高血压病患者中的临床意义。方法选103例高血压病患者及30例正常者空腹取肘静脉血采用酶联免疫吸附双抗体夹心法(ELISA)，测定血浆vWF含量。按高血压病分期及年龄段分组。结果高血压Ⅱ、Ⅲ期患者vWF含量显著高于正常对照组(P<0.01)，随着年龄增大，vWF的含量也增高，同时70岁以上年龄段中男性升高最明显。结论vWF是血管内皮受损的标志物，高血压患者存在内皮细胞受损，受损程度与年龄大小,病情正相关。

Clinical Significance of VWF in Patients with Essential Hypertension

Aim To explore the clinical significance of the vWF in the patients with essential hypertension(EH). Methods vWF were measured with enzyme linked immunoabsorbent assay(ELISA) in 103 EH patients and 30 normal controls. The vWF values were compared by age ,gender,and stages of hypertension. Results There were markedly rise in EH patients than that in the normal controls. The vWF was increased with the age and stage of hypertension. The highest vWF was found in male over seventy years. Conclusion vWF may serve as an indicator of injury of endothelium. A positive correlation between endothelium lesion and age was found.