Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature

Authors:	Kunal Malik Helen He Thy Nhat Huynh Gary Tran Kelly Mueller Kristina Doytcheva Yael Renert-Yuval Tali Czarnowicki Shai Magidi Margaret Chou Yeriel D. Estrada Huei-Chi Wen Xiangyu Peng Hui Xu Xiuzhong Zheng James G. Krueger Amy S. Paller Emma Guttman-Yassky

Affiliation:	1. Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY;2. Laboratory for Investigative Dermatology, Rockefeller University, New York, NY;3. Departments of Dermatology and Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill;4. Department of Dermatology, Hebrew University Medical Center, Jerusalem, Israel

Abstract:

Keywords:	Psoriasis atopic dermatitis immune inflammation epidermal barrier Netherton syndrome congenital ichthyosiform erythroderma lamellar ichthyosis epidermolytic ichthyosis IL-17 TNF-α IL-36 targeted therapy precision medicine AD Atopic dermatitis ARCI Autosomal recessive congenital ichthyosis CCL17 Chemokine like 17 CE Cornified envelope CIE Congenital ichthyosiform erythroderma CLDN Claudin DEG Differentially expressed gene EI Epidermolytic ichthyosis EREG Epiregulin FCH Fold change FDR False discovery rate FLG Filaggrin IASI Ichthyosis Area and Severity Index IASI-E Ichthyosis Area and Severity Index–erythema IASI-S Ichthyosis Area and Severity Index–scaling IL-36R IL-36 receptor KLK Kallikrein KYNU Kynureninase LI Lamellar ichthyosis LOR Loricrin NS Netherton syndrome OASL 2′-5′-oligoadenylate synthetase-like protein PPL Periplakin SC Stratum corneum TEWL Transepidermal water loss TJ Tight junction TSLP Thymic stromal lymphopoietin VNN3 Vanin 3
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