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Role of reduced-intensity conditioning allogeneic hematopoietic cell transplantation in older patients with de novo acute myeloid leukemia

Authors:	Satoshi?Yamasaki author-information" > author-information__contact u-icon-before" > mailto:yamas@kyumed.jp" title=" yamas@kyumed.jp" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Akihiro?Hirakawa,Jun?Aoki,Naoyuki?Uchida,Takahiro?Fukuda,Hiroyasu?Ogawa,Kazuteru?Ohashi,Tadakazu?Kondo,Tetsuya?Eto,Heiwa?Kanamori,Hirokazu?Okumura,Koji?Iwato,Tatsuo?Ichinohe,Junya?Kanda,Makoto?Onizuka,Yachiyo?Kuwatsuka,Masamitsu?Yanada,Yoshiko?Atsuta,Akiyoshi?Takami,Shingo?Yano

Affiliation:	1.Department of Hematology and Clinical Research Institute,National Hospital Organization Kyushu Medical Center,Chuo-ku,Japan;2.Biostatistics and Bioinformatics Section, Center for Advanced Medicine and Clinical Research,Nagoya University Hospital,Nagoya,Japan;3.Department of Hematology,Kanagawa Cancer Center,Kanagawa,Japan;4.Department of Hematology,Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital,Tokyo,Japan;5.Division of Hematopoietic Stem Cell Transplantation,National Cancer Center Hospital,Tokyo,Japan;6.Division of Hematology, Department of Internal Medicine,Hyogo College of Medicine,Kobe,Japan;7.Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center,Komagome Hospital,Tokyo,Japan;8.Department of Hematology/Oncology,Kyoto University Hospital,Kyoto,Japan;9.Department of Hematology,Hamanomachi Hospital,Fukuoka,Japan;10.Department of Internal Medicine,Toyama Prefectural Central Hospital,Toyama,Japan;11.Department of Hematology,Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital,Hiroshima,Japan;12.Department of Hematology and Oncology,Hiroshima University Hospital,Hiroshima,Japan;13.Division of Hematology, Saitama Medical Center,Jichi Medical University,Shimotsuke,Japan;14.Department of Hematology/Oncology,Tokai University School of Medicine,Isehara,Japan;15.Center for Advanced Medicine and Clinical Research,Nagoya University Hospital,Nagoya,Japan;16.Department of Hematology,Fujita Health University School of Medicine,Toyoake,Japan;17.Department of Healthcare Administration,Nagoya University Graduate School of Medicine and Japanese Data Center for Hematopoietic Cell Transplantation,Nagoya,Japan;18.Department of Hematology,Aichi Medical University,Nagoya,Japan;19.Division of Clinical Oncology and Hematology, Department of Internal Medicine,Jikei University School of Medicine,Tokyo,Japan

Abstract:	Reduced-intensity conditioning (RIC) regimens extend the therapeutic use of allogeneic hematopoietic cell transplantation (HCT) to older patients. The survival trend in 2325 patients aged >50 years presenting with de novo acute myeloid leukemia (AML) who underwent first reduced-intensity HCT (RIC-HCT) was assessed by retrospectively analyzing outcomes between 2000 and 2013. The annual number of RIC-HCTs in Japan was higher in the 2008–2013 period (n?=?205/year [1229/6 years]) than in the 2000–2007 period (n?=?137/year [1096/8 years]). Overall and disease-free survival were higher in the 2008–2013 period (P?

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