| 红花黄色素对氧自由基引起人红细胞膜损伤的保护作用 |
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| 引用本文： | 周璐,王媛凯,张立伟.红花黄色素对氧自由基引起人红细胞膜损伤的保护作用[J].山西中医学院学报,2011,12(4):19-21. |
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| 作者姓名： | 周璐 王媛凯 张立伟 |
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| 作者单位： | 山西大学分子科学研究所,山西,太原,030006 |
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| 基金项目： | 科技部十二五“重大新药创制”科技重大专项项目(2011ZX09201-201-06); 山西省回国留学人员科研资助项目基金(2009003); 太原市大学生创新创业计划项目基金(100115151) |
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| 摘 要： | 目的:研究羟基红花黄色素A(HSYA)和红花黄色素B(SYB)对超氧阴离子自由基(O2-.)引发的人红细胞膜氧化损伤的保护作用。方法:采用邻苯三酚制备人红细胞膜过氧化损伤模型,研究HSYA和SYB对人红细胞膜氧化损伤的影响。结果:O2-.能引起红细胞膜脂质过氧化,使膜流动性下降。而红细胞膜经过一定量的HSYA和SYB预处理后,膜流动性提高。结论:HSYA和SYB对氧自由基引发的红细胞膜损伤具有一定的保护作用。
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| 关 键 词： | 羟基红花黄色素A 红花黄色素B 红细胞膜 过氧化损伤 |
Protective Effect of Safflor Yellow on Damage of Erythrocyte Membrane by Oxygen Free Radicals |
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| Zhou Lu,Wang Yuankai,Zhang Liwei.Protective Effect of Safflor Yellow on Damage of Erythrocyte Membrane by Oxygen Free Radicals[J].Journal of Shanxi College of Traditional Chinese Medicine,2011,12(4):19-21. |
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| Authors: | Zhou Lu Wang Yuankai Zhang Liwei |
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| Institution: | Zhou Lu,Wang Yuankai,Zhang Liwei(Institute of Molecular Science of Shanxi University,Taiyuan Shanxi 030006) |
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| Abstract: | Objective:To study the protective effect of hydroxysafflor yellow A(HSYA)and safflor yellow B(SYB)on the oxidative damage of erythrocyte membrane.Methods:Oxidative damage of the erythrocyte membrane induced by superoxide anion(O2-.)from the auto-oxidation of pyrogallic acid was used as model.The effect of HSYA and SYB on oxidated erythrocyte membrane was observed.Results:O2-.caused lipid peroxidation of erythrocyte membrane and decreased membrane fluidity.However,pretreatment with HSYA and SYB respectively ... |
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| Keywords: | hydroxysafflor yellow A safflor yellow B erythrocyte membrane peroxidative damage |
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