TRP channels: a TR(I)P through a world of multifunctional cation channels |
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Authors: | Bernd Nilius Thomas Voets |
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Institution: | (1) Laboratorium voor Fysiologie, Department of Physiology, Campus Gasthuisberg, KU Leuven, Leuven, 3000, Belgium |
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Abstract: | The transient receptor potential (TRP) family of ion channels comprises more than 50 cation-permeable channels expressed from yeast to man. On the basis of structural homology, the TRP family can be subdivided in to seven main subfamilies: the TRPC ( Canonical ) group, the TRPV ( Vanilloid ) group, the TRPM ( Melastatin ) group, the TRPP ( Polycystin ), the TRPML ( Mucolipin ), the TRPA ( Ankyrin ) and the TRPN ( NOMP ) family. The cloning and characterization of members of this cation channel family has exploded during recent years, leading to a plethora of data concerning TRPs in a variety of cell types, tissues and species. This paper briefly reviews the TRP superfamily and the basic properties of its many members as a reader s guide in this Special Issue. Hopefully, a better understanding of TRP channel physiology will provide important insight into the relationship between TRP channel dysfunction and human diseases. |
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