支气管哮喘患者血清嗜酸细胞阳离子蛋白的变化

探讨检测血清嗜酸细胞阳离子蛋白在支气管哮喘的诊断１病情监测及疗效判断中的价值。方法采用荧光酶免疫法测定了发作期和缓解哮喘患者各２０例，慢性阻塞性肺疾病患者１６例和正常人２０例的血清ＥＣＰ，同时进行了肺功能测定，并对发作期哮喘患者在给予吸入皮质激素治疗３ｍｏ后复测其ＥＣＰ及肺。

Clinicalsigificance of serum eosinophil cationic protein in patients with bronchial asthma

Aim To explore the role of serum eosinophil cationic protein(ECP) in the diagnosis, monitoring and curative effect assessment of asthma. Methods Serum ECP level was detected with Pharmacia CAP system in 20 severe asthma patients, 20 stable asthmatic patients, 16 patients with chronic obstructive pulmonary disease(COPD) and 20 normal individuals. At the same time their lung function(FEV1%) was also detected. In the first group after inhaled steroid treatment for three months their serum ECP level and FEV1%were redetected. Results Before the treatment, serum ECP levels in severe asthma patients were significantly higher than those in stable asthma patients,COPD and normal individuals(P<0.01), and serum ECP in stable asthma patients were also higher than those in COPD group and in normal individuals (P<0.05 and P<0.01). But there was no significant difference of lung function among three groups. After anti inflammation treatment, serum ECP level in severe asthma patient was significantly decreased, and lung function also was improved, with negative correlation(r=0.735, P<0.05). Conclusion Serum ECP level could directly reflect airway inflammatory degree and help predicting the asthma exacerbation and its severity. Kinetic measurement of serum ECP level could instruct controlled status of airway inflammation. Also could more effectively assess the efficacy of anti inflammatory treatment.