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| 重型脑外伤患者血浆抵抗素水平动态变化与预后的关系 | |
| 引用本文： | 杨松斌,王克义,竹方龙,吕庆伟,章国海,黄杭斌,秦智勇.重型脑外伤患者血浆抵抗素水平动态变化与预后的关系[J].中国临床神经科学,2011,19(3):265-269. |
| 作者姓名： | 杨松斌 王克义 竹方龙 吕庆伟 章国海 黄杭斌 秦智勇 |
| 作者单位： | 1. 浙江省嵊州市人民医院神经外科,312400 2. 杭州市第一人民医院检验科,310006 3. 复旦大学附属华山医院神经外科,200040 |
| 摘 要： | 目的:研究血浆抵抗素水平与重型脑外伤预后的相关性。方法:取80例重型脑外伤患者在入院时及入院后第1、2、3、5、7天静脉血,另取80例体检健康者静脉血做对照。用ELISA法测定血浆抵抗素浓度,分析血浆抵抗素水平与格拉斯哥(GCS)评分及死亡的相关性,以及抵抗素水平对重型脑外伤患者1个月内死亡的预测特异度和敏感度。结果:脑外伤后第1、2、3、5、7天血浆抵抗素水平明显增高。入院时血浆抵抗素水平增高是脑外伤1个月内死亡的危险因素(P=0.042),与入院时GCS评分呈显著负相关(P<0.001),对脑外伤后患者1个月内死亡有显著预测价值(P<0.001)。结论:脑外伤后血浆抵抗素水平显著增高,可作为重型脑外伤患者预后判断的重要指标。 |
| 关 键 词： | 抵抗素 脑外伤 预后 |
Dynamic Changes of Plasma Resistin Level in Patients with Serious Traumatic Brain Injury and Its Association with Prognosis |
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| YANG Song-Bin,Wang Ke-Yi,ZHU Fang-Long,LV Qing-Wei,ZHANG Guo-Hai,HUANG Hang-Bin,QIN Zhi-Yong.Dynamic Changes of Plasma Resistin Level in Patients with Serious Traumatic Brain Injury and Its Association with Prognosis[J].Chinese Journal of Clinical Neurosciences,2011,19(3):265-269. | |
| Authors: | YANG Song-Bin Wang Ke-Yi ZHU Fang-Long LV Qing-Wei ZHANG Guo-Hai HUANG Hang-Bin QIN Zhi-Yong |
| Institution: | 1Department of Neurosurgery, Shengzhou People’s Hospital, Shenzhou, 312400; 2Department of Laboratory Medicine, Hangzhou First People’s Hospital, Hangzhou, 310006; 3Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China |
| Abstract: | Aim: To determine the correlation of plasma resistin level with disease outcome in patients with serious traumatic brain injury (TBI). Methods: Venous blood was obtained from 80 cases on admission at day 1, 2, 3, 5, and 7 after TBI. Plasma resistin concentration was measured by enzyme-linked immunosorbent assay. Venous blood from 80 healthy people was also measured as control. Results: After TBI, plasma resistin level increased significantly. Plasma resistin level on admission was an independent predictor f... |
| Keywords: | resistin traumatic brain injury prognosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |