| 大剂量地塞米松联合乌司他丁治疗严重肺挫伤 |
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| 引用本文： | 陈喜云,钮海弟,徐善明,钟金龙.大剂量地塞米松联合乌司他丁治疗严重肺挫伤[J].中国临床医学,2011,18(1):62-63,65. |
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| 作者姓名： | 陈喜云 钮海弟 徐善明 钟金龙 |
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| 作者单位： | 复旦大学附属金山医院胸外科,上海,200540 |
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| 摘 要： | 目的：研究大剂量地塞米松联合乌司他丁治疗严重肺挫伤的疗效与安全性。方法：选择58例严重肺挫伤患者,随机分为A组（n=29）和B组（n=29）。A组接受常规治疗,包括使用地塞米松20~40mg,2次/d,连续3d。B组在常规治疗的基础上联合乌司他丁20万U加入0.9%氯化钠液100mL静脉滴注,每8h1次,连用7d;2组患者治疗第1、第7天行血气分析,并检测治疗第1、第4、第7天血清肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）的含量。比较治疗期间2组患者急性呼吸窘迫综合征（ARDS）的发生率。结果：治疗前2组血气分析指标及血清TNF-α、IL-6水平无显著差异（P〉0.05）;治疗后B组血气分析指标较同期A组显著改善（P〈0.05）,血清TNF-α、IL-6水平较A组显著下降更明显（P〈0.05）。ARDS发生率B组显著低于A组（P〈0.05）。结论：大剂量地塞米松联合应用乌司他丁能显著抑制炎症介质的释放,有效保护严重肺挫伤患者的肺功能。
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| 关 键 词： | 地塞米松 乌司他丁 肺挫伤 治疗 |
Therapeutic Effects of High Dose Dexamethasone Combined with Ulinastatin in Treating Sever Pulmonary Contusion |
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| CHEN Xiyun,NIU Haidi,XU Shanming,ZHONG Jinlong.Therapeutic Effects of High Dose Dexamethasone Combined with Ulinastatin in Treating Sever Pulmonary Contusion[J].Chinese Journal Of Clinical Medicine,2011,18(1):62-63,65. |
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| Authors: | CHEN Xiyun NIU Haidi XU Shanming ZHONG Jinlong |
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| Institution: | CHEN Xiyun NIU Haidi XU Shanming ZHONG Jinlong Department of Thoracic Surgery,Jinshan Hospital,Fudan University,Shanghai 200540,China |
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| Abstract: | Objective:To observe the therapeutic effects of high dose dexamethasone combined with Ulinastatin in treating sever pulmonary contusion.Methods:A total of 58 patients with sever pulmonary contusion were randomly divided into Group A(n=29) and Group B(n=29).Both Groups received routine treatment,including dexamethasone(20-40 mg intravenous drip twice one day and continued 3 days),while the patients of Group B(n=29) were given Ulinastatin(200 kU intravenous drip once every 8 hours and continued 7 days) in add... |
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| Keywords: | Dexamethasone Ulinastatin Pulmonary contusion Treatment |
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