| 藏药柳茶提取物对非酒精性脂肪肝病大鼠肝脏保护作用及其机制研究 |
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| 引用本文： | 王晶宇,马晓燕,夏苗,刘昕.藏药柳茶提取物对非酒精性脂肪肝病大鼠肝脏保护作用及其机制研究[J].中国临床药理学杂志,2011,27(3):191-194. |
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| 作者姓名： | 王晶宇 马晓燕 夏苗 刘昕 |
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| 作者单位： | 兰州大学基础医学院病理生理学研究所,兰州,730000 |
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| 基金项目： | 国家首届大学生创新计划基金资助项目，甘肃省中药管理局科技攻关基金资助项目 |
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| 摘 要： | 目的 研究藏药柳茶提取物(治疗胃胀痛及消化不良藏药)对非酒精性脂肪肝病(NAFLD)大鼠肝脏保护作用的机制.方法 用高脂饮食复制NAFLD大鼠模型,随机分为4组:模型组、柳茶提取物低、中、高剂量组;同时设立正常对照组,相应干预8周后,处死.制作肝组织切片观察形态变化;检测血清ALT,AST水平;荧光定量RT-PCR法测...
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| 关 键 词： | 藏药柳茶提取物 非酒精性脂肪肝病 抗氧化酶 |
Study on protective effect and mechanism of Liucha extract on hepatic injury of rats induced by non-alcoholic fatty liver disease |
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| WANG Jing-yu,MA Xiao-yan,XIA Miao,LIU Xin.Study on protective effect and mechanism of Liucha extract on hepatic injury of rats induced by non-alcoholic fatty liver disease[J].The Chinese Journal of Clinical Pharmacology,2011,27(3):191-194. |
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| Authors: | WANG Jing-yu MA Xiao-yan XIA Miao LIU Xin |
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| Institution: | WANG Jing-yu,MA Xiao-yan,XIA Miao,LIU Xin(Institute of Pathophysiology,Preclinical Medical College,Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | Objective To investigate the protective mechanism of Liucha extract against non-alcoholic fatty liver disease(NAFLD)in rats.Methods NAFLD models of SD rats were established by high fat diet feeding for 6 weeks,and then divided randomly into four groups: the model group,low-,medium-and high-dosage Liucha extract treatment groups.A normal control group was also run.Eight weeks later,all rats were killed.Hepatic morphological changes were observed under light microscope and liver function parameters(ALT,AST) w... |
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| Keywords: | Liucha extract non-alcoholic fatty liver disease antioxidase |
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