TCD对颅内动脉狭窄或闭塞诊断的临床研究

目的分析经颅多普勒超声(TCD)对颅内动脉狭窄或闭塞诊断的意义。方法回顾性分析50例疑为颅内动脉狭窄或闭塞的脑血管病患者(观察组)和30例正常体检者(对照组)的TCD结果(主要针对大脑中动脉、大脑前动脉、椎动脉和基底动脉等血管),并与MRA及DSA结果作对比分析。结果观察组与对照组所查脑血管平均血流速度有明显差异(P<0.05);以DSA检查为金标准,TCD结果的假阳性率为17.2%,假阴性率为17.1%,特异性为82.8%,敏感性为82.9%;与MRA检查相比,对颅内动脉狭窄或闭塞的阳性检出率无显著差异(P>0.05)。结论 TCD可作为诊断颅内动脉狭窄和闭塞的常用辅助检查手段。

Value of transcranial Doppler ultrasonography to diagnosis of intracranial artery stenosis or occlusion

Objective To investigate the value of transcranial Doppler ultrasonography （TCD） to diagnosing intracranial artery stenosis or occlusion. Methods TCD, MRA and DSA examinations were performed in 50 patients who were suspected of suffering from intracranial artery stenosis or occlusion and TCD examination was performed in 30 normal subjects. All the findings by TCD,MRA and DSA were analyzed. Results The velocities of mean blood flow of the middle cerebral artery, anterior cerebral artery, basilar artery and vertebral artery were significantly faster in the patients who were suspected of suffering from intracranial artery stenosis or occlusion than those in the normal subjects （P0.05）. According to DSA serving as gold standard, the false positive rate of TCD was 17.2%, its false negative rate was 17.1%, its specificity was 82.8%, and its sensitivity was 82.9%. There was no significant difference in the positive rate between TCD and MRA in the patients who were suspected of suffering from the intracranial artery stenosis or occlusion （P0.05）. Conclusions TCD, which is very helpful to diagnosis of intracranial artery stenosis and occlusion, may be used as a routine examination in the patients who are suspected of suffering from intracranial artery stenosis or occlusion.