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| 痰中检测核不均一核糖核蛋白A2/B1早期诊断肺癌的意义 | |
| 引用本文： | 石园,陈颖,胡沁,季春华,侯英勇,周杨,宿杰阿克苏,谭云山.痰中检测核不均一核糖核蛋白A2/B1早期诊断肺癌的意义[J].中国临床医学,2011,18(2):142-144. |
| 作者姓名： | 石园 陈颖 胡沁 季春华 侯英勇 周杨 宿杰阿克苏 谭云山 |
| 作者单位： | 1. 复旦大学附属中山医院病理科,上海,200032 2. 复旦大学附属肿瘤医院病理科,上海,200032 3. 上海市第五人民医院胸外科,上海,200240 |
| 摘 要： | 目的：探讨检测痰中核不均一核糖核蛋白A2/B1（heterogeneous nuclear ribonucleoprotein A2/B1,hnRNP A2/B1）在肺癌早期诊断中的意义。方法：收集63例疑诊肺癌患者的痰标本,分别采用痰涂片、痰细胞块切片细胞学检查（镜检找到癌细胞即诊断为肺癌）及痰细胞块切片免疫组织化学检测hnRNP A2/B1（表达阳性即诊断为肺癌）进行诊断,比较2种诊断方法的结果。结果：痰涂片及痰细胞块切片细胞学检查诊断肺癌的敏感度为31.8%,特异度为100%。痰细胞块检测hnRNP A2/B1诊断肺癌的敏感度为80%,特异度为68.4%。检测痰hnRNP A2/B1的敏感度显著高于痰细胞学检查（P〈0.01）。结论：痰细胞块结合免疫组织化学法检测hnRNP A2/B1有助于发现早期肺癌。 |
| 关 键 词： | 核不均一核糖核蛋白A2/B1 痰 细胞块 免疫组织化学 |
The Value of hnRNP A2/B1 Expression in Sputum for Early Diagnosis of Lung Cancer |
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| SHI Yuan,CHEN Ying,HU Qin,JI Chunhua,HOU Yingyong,ZHOU Yang,SU Jieakesu,TAN Yunshan.The Value of hnRNP A2/B1 Expression in Sputum for Early Diagnosis of Lung Cancer[J].Chinese Journal Of Clinical Medicine,2011,18(2):142-144. | |
| Authors: | SHI Yuan CHEN Ying HU Qin JI Chunhua HOU Yingyong ZHOU Yang SU Jieakesu TAN Yunshan |
| Institution: | SHI Yuan1 CHEN Ying2 HU Qin1 JI Chunhua3 HOU Yingyong1 ZHOU Yang1 SU Jieakesu1 TAN Yunshan1 1.Department of Pathology,Zhongshan Hospital,Fudan University,Shanghai 200032,China,2.Department of Pathology,Cancer Hospital,3.Department of thoracic surgery,The Fifth People's Hospital of Shanghai,Shanghai 200240 |
| Abstract: | Objective:To investigate the value of hnRNP A2/B1 expression in sputum for early diagnosis of lung cancer.Methods: A total of 63 sputum specimens of patients who were suspected as lung cancer were collected to compare the regular examination of sputum cells with detection of hnRNP A2/B1 by immunohistochemical staining method.Results: The sensitivity and specificity of regular examination of sputum cells were 31.8% and 100%,while the detection of hnRNP A2/B1 by immunohistochemical staining method were 80% an... |
| Keywords: | Heterogeneous nuclear ribonucleoprotein A2/B1(hnRNP A2/B1) Sputum Cell block Immunohistochemistry |
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