黄连素对2型糖尿病大鼠主动脉内皮功能及形态的保护作用 |
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引用本文: | 张明,王春梅,吕晓艳,王云晶,刘洁,陈立,王春艳. 黄连素对2型糖尿病大鼠主动脉内皮功能及形态的保护作用[J]. 中国老年学杂志, 2011, 31(7): 1160-1163 |
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作者姓名: | 张明 王春梅 吕晓艳 王云晶 刘洁 陈立 王春艳 |
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作者单位: | 1. 吉林大学白求恩医学院药理教研室,吉林,长春,130021 2. 北华大学药学院 3. 吉林大学第一医院 |
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基金项目: | 国家自然科学基金资助课题 |
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摘 要: | 目的 通过观察黄连素对2 型糖尿病大鼠血管内皮功能的影响,探讨黄连素对2型糖尿病血管并发症的防治意义及其机制.方法 采用小剂量链脲佐菌素腹腔注射加高脂饲料喂养的方法建立2型糖尿病大鼠模型,将模型动物随机分为模型组、黄连素治疗组,另设正常对照组以及正常黄连素组.药物干预治疗8 w后,处理动物,检测各组动物血清中空腹血糖(...
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关 键 词: | 黄连素 糖尿病 血管内皮 内皮功能障碍 |
Protective effects of berberine on aortic endothelial function in type 2 diabetic rats |
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Affiliation: | ZHANG Ming,WANG Chun-Mei,Lü Xiao-Yan,et al.Basic Medical College of Jilin University,Changchun 130021,Jilin,China |
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Abstract: | Objective To investigate the effects of berberine on vascular endothelial function in type 2 diabetic rats and explore its prophylactic and therapeutic significance and pharmacological mechanism.Methods Wistar rats were randomly divided into diabetic,control,diabetic rats treated with berberine(100 mg/kg),and control rats treated with berberine groups.The serum fasting plasma glucose(FPG),insulin,total cholesterol(TC),triglyceride(TG) levels were tested.Acetylcholine(ACh) induced endothelium-dependent relax... |
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Keywords: | Berberine Diabetes Vascular endothelium Endothelial dysfunction |
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