人脑胶质瘤中ING4和CTGF的表达及其意义

目的 探讨人脑胶质瘤中生长抑制因子4(ING4)及结缔组织生长因子(CTGF)的mRNA的表达及其意义.方法 采用荧光实时定量聚合酶链式反应法检测ING4和CTGF mRNA在30例脑胶质瘤组织和5例正常脑组织中的表达水平,统计分析表达水平和肿瘤级别之间的关系以及二者表达水平的相天性.结果 ING4 mRNA在Ⅰ～Ⅱ级...

Study of expressions of ING4 and CTGF in human gliomas and their meanings

Objective To study the expressions of ING4 and CTGF in human gliomas and their meanings.Methods The expressions of CTGF and ING4 mRNA in 30 specimens of human gliomas and 5 normal brain tissues were determined by real time polymerase chain reaction.Their relationship with pathological grades was analyzed.Results The level of ING4 mRNA expression in the human gliomas was significantly lower than that in the normal brain tissues （P0.01）.The level of ING4 mRNA expression in grades Ⅲ～ Ⅳ gliomas was significantly lower than that in grades Ⅰ～Ⅱ gliomas （P0.01）.The levels of CTGF mRNA expression in the human gliomas was significantly higher than that in the normal brain tissues （P0.01）.The level of CTGF mRNA expression in grades Ⅲ～Ⅳ gliomas was significantly higher than that in gradesⅠ～Ⅱ gliomas （P0.01）.The level of ING4 mRNA expression was negatively related to that of CTGF mRNA expression in the gliomas （γ=-0.723,P0.05）.Conclusions The expression of ING4 mRNA in the gliomas is negtively related to the malignant degree of the tumors.The expression of CTGF mRNA in the gliomas is positively related to the malignant degree of the tumors.It is suggested that ING4 and CTGF may play an important role in the phatholgenesis and development of the human glioma.