甲状腺功能异常与复发性流产关系分析

目的:探讨甲状腺功能异常与复发性自然流产的关系,为临床治疗提供理论基础。方法:甲状腺功能异常的有复发性流产史者128例为研究对象,分娩前病情得到控制者作为实验组,共67例,病情无法控制到正常标准者为对照组,共61例。应用化学发光法检测两组患者血清中FT3、FT4及TSH水平。结果:实验组甲状腺功能亢进患者30例,占44.8%,甲状腺功能减低患者37例,占55.2%;对照组甲状腺功能亢进患者有29例,占47.5%,甲状腺功能减低患者32例,占52.5%,两组间甲状腺功能异常构成比无统计学差异(P>0.05)。实验组流产11例,发病率为16.4%,对照组流产33例,发病率为54.1%,对照组流产发生率明显高于实验组(P<0.01)。结论:甲状腺功能异常可以导致复发性流产发生率升高,与复发性自然流产发生存在相关性。

Analysis on relationship between thyroid dysfunction and recurrent spontaneous abortion

Objective:To explore the relationship between thyroid dysfunction and recurrent spontaneous abortion(RSA),provide a theoretical basis for clinical treatment.Methods:A total of 128 RSA patients with thyroid dysfunction were selected as research objects,67 patients who controlled the disease before delivery were selected as experimental group,while 61 patients out of control were selected as control group.Chemiluminescence method was used to detect the serum levels of free T3(FT3),free T4(FT4),and follicle stimulating hormone(FSH) in the two groups.Results:In experimental group,30 patients were diagnosed as hyperthyroidism,accounting for 44.8%;37 patients were diagnosed as hypothyroidism,accounting for 55.2%.In control group,29 patients were diagnosed as hyperthyroidism,accounting for 47.5%;32 patients were diagnosed as hypothyroidism,accounting for 52.5%.There was statistically significant difference in the proportion of thyroid dysfunction between the two groups(P>0.05).The incidences of abortion in experimental group and control group were 16.4%(11 patients) and 54.1%(33 patients),respectively.The incidence of abortion in control group was statistically significantly higher than that in experimental group(P<0.01).Conclusion:Thyroid dysfunction can induce the increase of incidence of RSA,there is correlation between thyroid dysfunction and RSA.