小细胞类乳腺癌细针穿刺细胞形态学观察

目的:探讨小细胞类乳腺癌细针穿刺的细胞形态学特点及鉴别诊断。方法:观察33例小细胞类乳腺癌细针穿刺细胞学涂片与93例乳腺纤维腺瘤和76例乳腺增生症并进行对照分析。结果:小细胞类乳腺癌中,细胞排列紊乱、松散,以散在或小细胞群为主,易见腺腔样、腺管样、炮竹式、栅栏状、单列纵队样排列,圆形核细胞占绝大多数,核质比明显减小,散在细胞易见、圆形核占多数、胞质完整,未见肌上皮细胞的相对病例数,均明显高于乳腺纤维腺瘤、乳腺增生症的相对病例数,差异均有统计学意义(P<0.05);细胞量中等以上的相对病例数,明显高于乳腺增生症,差异有统计学意义(P<0.05);纤维间质及其与乳腺上皮细胞混杂的相对病例数,明显低于乳腺纤维腺瘤,差异均有统计学意义(P<0.05)。结论:小细胞类乳腺癌具有不同于乳腺纤维腺瘤和乳腺增生症的细针穿刺细胞形态学特点,与乳腺纤维腺瘤、乳腺增生症可以鉴别。

Cell morphological observation of small cell breast cancer by fine needle puncture

Objective:To explore the cell morphological characteristics and differential diagnosis of small cell breast cancer by fine needle puncture.Methods:The cytological smears of 33 cases with small cell breast cancer were observed,then the results were compared with those of 93 cases with breast fibroadenoma and 76 cases with breast hyperplasia.Results:The cytological smears of 33 cases with small cell breast cancer showed that the distribution of cells was disorder and loose,diffuse cells and small cell mass dominated,the glandular cavities,glandular tubes,firecrackers,fences,and single columns arranged,most of the cells were round nucleic cells,the nucleoplasm reduced significantly,diffuse cells were easily to be found,most of the cells had round nuclei,and cytoplasm was intact,the relative number of cases without myoepithelial cells was statistically significantly higher than those of cases with breast fibroadenoma and breast hyperplasia(P<0.05).The relative number of cases with moderate amount of cells was statistically significantly higher than at of cases with breast hyperplasia(P<0.05).The relative number of cases with fibrous stroma and mixed breast epithelial cells was statistically significantly lower than that of cases with breast fibroadenoma(P<0.05).Conclusion:The cell morphological characteristics of small cell breast cancer were different from those of breast fibroadenoma and breast hyperplasia by fine needle puncture,so it can be identified from breast fibroadenoma and breast hyperplasia by fine needle puncture.