小儿幽门螺杆菌感染伴消化性溃疡的临床治疗方法对比分析

目的:探讨小儿幽门螺杆菌(Hp)感染伴消化性溃疡的不同临床治疗方法的疗效。方法:将60例平均年龄(7±0.6)岁幽门螺杆菌感染伴消化性溃疡的患儿采用随机数字法平均分为3组,所有患者均阿莫西林和甲硝唑治疗,同时A组患者给予奥美拉唑2周治疗,B组患者给予雷尼替丁4周治疗,C组患者给予胶体枸椽酸铋4周治疗。治疗后再次应用快速尿素酶试验联合14C-尿素呼吸试验检查Hp感染,并通过胃镜检测患者溃疡愈合情况。结果:治疗后3组间疗效比较结果显示:3组患者治疗后差异比较有统计学意义(P<0.05);进一步行两两比较显示,A组(奥美拉唑组)患者及C组(胶体枸椽酸铋组)患者愈合人数、Hp根除人数均多于B组(雷尼替丁组)患者,愈合时间及Hp根除时间明显低于B组(雷尼替丁组)患者,差异比较有统计学意义(P<0.05);A组(奥美拉唑组)患者与C组(胶体枸椽酸铋组)患者比较差异无统计学意义(P>0.05)。结论:对幽门螺杆菌感染伴消化性溃疡的患儿行奥美拉唑或胶体枸椽酸铋联合甲硝唑及阿莫西林治疗可以显著缓解患者的症状,同时与雷尼替丁相比,其治愈时间比较短,值得临床推广应用。

Comparative analysis on clinical therapeutic methods for the infants with helicobacter pylori infection combined with peptic ulcer

Objective:To explore the curative effects of different clinical therapies for the infants with helicobacter pylori infection combined with peptic ulcer.Methods:A total of 60 infants with helicobacter pylori infection combined with peptic ulcer whose mean age was(7±0.6) years were randomly divided into three groups according to random number table,20 infants in each group;all the infants were treated with amoxicillin and metronidazole,at the same time,the infants in group A were treated with prilosec for two weeks,the infants in group B were treated with ranitidine for four weeks,and the infants in group C were treated with colloid bismuth citrate for four weeks.After treatment,rapid urease test and 14C-urea breathing test were used to detect helicobacter pylori infection,gastroscope was used to detect healing situation of ulcer.Results:There was statistically significant difference in the curative effect among the three groups(P<0.05);the healing number of ulcer and elimination number of helicobacter pylori in group A and group C were statistically significantly higher than those in group B,the healing time of ulcer and elimination time of helicobacter pylori in group A and group C were statistically significantly lower than those in group(P<0.05),but there was no statistically significant difference between group A and group C(P>0.05).Conclusion:For the infants with helicobacter pylori infection combined with peptic ulcer,prilosec or colloid bismuth citrate combined with metronidazole and amoxicillin can relieve the symptoms of the infants,compared with ranitidine,the healing time of ulcer is shorter,the method is worthy to be popularized in clinic.