卵巢低反应中胚胎移植时间与临床妊娠率的关系

目的:探讨在卵巢低反应周期中,不同胚胎移植时间对临床妊娠率的影响。方法 :回顾性分析卵巢低反应患者行IVF-ET治疗74个周期的资料,比较受精方式、优质胚胎数、可利用胚胎数、卵裂球的细胞数,48 h组与72 h组的获卵数、受精率、卵裂率、优胚率、可利用胚胎率、临床妊娠率。结果:48 h(IVF20个周期与ICSI13个周期)组与72 h(26/IVF与15/ICSI)组间的年龄、不育年限、用药方案等差异均无统计学意义(P>0.05);两组受精率、卵裂率比较差异无统计学意义(P>0.05);优胚率48 h组较72 h组有所提高,但组间比较差异无统计学意义(P>0.05);可利用胚胎率、ET胚胎数、临床妊娠率两组比较差异均有统计学意义(P<0.05)。结论 :卵巢低反应周期,48h胚胎移植不仅能提高优质胚胎率、可利用胚胎率,还能增加移植胚胎数及临床妊娠率,减少周期取消率。

Relationship between embryo transfer time and clinical pregnancy rate during poor ovarian response cycles

Objective:To explore the effects of different embryo transfer times on clinical pregnancy rate during poor ovarian response cycles.Methods:The data of patients with poor ovarian response receiving IVF-ET(74 cycles) were analyzed retrospectively;the insemination ways,the numbers of high quality embryos,the numbers of available embryos,and the numbers of blastomere were compared;the numbers of retrieved oocytes,the fertilization rates,the cleavage rates,the rates of high quality embryos,the rates of available embryos,and the clinical pregnancy rates in 48-hour group and 72-hour group were compared.Results:There was no statistically significant difference in the maternal age,duration time of infertility,and the therapeutic scheme between 24-hour group(20 IVF cycles and 13 ICSI cycles) and 72-hour group(26 IVF cycles and 15 ICSI cycles)(P>0.05);there was no statistically significant difference in the fertilization rate and cleavage rate between the two groups(P>0.05);the rate of high quality embryos in 48-hour group was higher than that in 72-hour group,but there was no statistically significant difference(P>0.05);there was statistically significant difference in the rate of available embryos,the number of embryos,and clinical pregnancy rate between the two groups(P<0.05).Conclusion:Embryo transfer at 48 hours during poor ovarian response cycles can increase the rate of high quality embryos,the rate of available embryos,the number of embryo transfer,and clinical pregnancy rate,reduce cycle cancellation rate.