腹腔镜手术联合药物治疗子宫内膜异位症伴不孕临床疗效分析

目的:分析腹腔镜手术联合药物治疗子宫内膜异位症伴不孕的临床疗效。方法:将收治的126例子宫内膜异位症伴不孕患者作为研究对象,遵照知情同意原则并按照随机数字表法分为两组,对照组62例采用腹腔镜手术治疗,观察组64例在对照组的基础上加用孕三烯酮治疗,比较分析两组的临床疗效。结果:观察组的总有效率为98.4%,对照组为87.1%,组间差异有统计学意义(P<0.05);两组患者治疗前血清CA125差异无统计学意义,治疗后两组患者的血清CA125均明显降低,分别与本组治疗前比较差异有统计学意义(P<0.05),组间差异无统计学意义(P>0.05);观察组的不良反应发生率为3.1%,对照组为8.1%,组间差异无统计学意义(P>0.05);观察组的妊娠率为29.7%,对照组为16.1%,组间差异有统计学意义(P<0.05)。结论:腹腔镜手术联合药物治疗子宫内膜异位症伴不孕临床疗效满意,明显优于单独的手术治疗且安全性可靠,是临床首选的治疗方案之一。

Analysis on clinical curative effect of laparoscopic surgery combined with drug therapy for treatment of infertile patients with endometriosis

Objective:To analyze the clinical effect of laparoscopic surgery combined with drug therapy for treatment of infertile patients with endometriosis.Methods:A total of 126 infertile patients with endometriosis who were treated in the hospital were selected as study objects,then they were divided into two groups in accordance with informed consent,62 infertile patients in control group were treated with laparoscopic surgery,while 64 patients in observation group were treated with gestrinone based on therapies used in control group.The curative effects in the two groups were compared and analyzed.Results:The total effective rates in observation group and control group were 98.4% and 87.1%,respectively,there was statistically significant difference between the two groups(P<0.05).There was no statistically significant difference in serum level of CAl25 before treatment between the two groups,but the serum levels of CA125 after treatment in the two groups decreased significantly,compared with before treatment,there was statistically significant difference(P<0.05),but there was no statistically significant difference between the two groups(P>0.05).The incidences of adverse reactions in observation group and control group were 3.1% and 8.1%,respectively,there was no statistically significant difference between the two groups(P>0.05).The pregnancy rates in observation group and control group were 29.7% and 16.1%,respectively,there was statistically significant difference between the two groups(P<0.05).Conclusion:The clinical efficacy of laparoscopic surgery combined with drug therapy for treatment of infertile patients with endometriosis is satisfied,which is superior to simple surgery,and the method is safe and reliable,which is the first choice in clinic.