单唾液酸四己糖神经节苷脂钠注射液治疗中、重度新生儿缺氧缺血性脑病疗效观察

目的:探讨应用单唾液酸四己糖神经节苷脂钠治疗中、重度新生儿缺氧缺血性脑病(HIE)的疗效及对预后的影响,为临床治疗提供参考依据。方法:将92例中、重度HIE患儿随机分为对照组和治疗组,两组均予支持疗法和对症处理,对照组应用胞二磷胆碱,而治疗组应用单唾液酸四己糖神经节苷脂钠,两组方法及疗程相同,最后比较两组NBNA评分。所有病例均于出生后3、6、9、12个月时测定发育商(DQ),对两组临床疗效及预后进行比较。结果:治疗组呼吸改善时间、惊厥消失时间、症状及体征全部消失时间少于对照组;治疗组后遗症发生率低于对照组,治疗组NBNA评分及DQ高于对照组,差异均具有统计学意义(P<0.01)。结论:与胞二磷胆碱相比,单唾液酸四己糖神经节苷脂钠治疗中、重度HIE的总有效率有所提高,患儿惊厥易于控制,意识障碍及肌张力等神经症状及体征恢复快,且在改善HIE的预后方面效果显著,可降低后遗症发生率及新生儿死亡率,无任何不良反应,适于临床推广使用。

Observation on the curative effect of monosialotetrahexosylganglioside sodium salt injection for treatment of neonates with moderate and severe hypoxic-ischemic encephalopathy

Objective:To explore the curative effect of monosialotetrahexosylganglioside sodium salt injection for treatment of neonates with moderate and severe hypoxic-ischemic encephalopathy(HIE) and its impact on prognosis,provide reference for clinical treatment.Methods:A total of 92 neonates with HIE were randomly divided into control group and treatment group,the neonates in the two groups received supporting treatment and symptomatic treatment,then the neonates in control group were treated with cytidine diphosphate choline,the neonates in treatment group were treated with monosialotetrahexosylganglioside sodium salt injection,the methods and courses of treatment in the two groups were the same,NBNA scores in the two groups were compared.Development quotients(DQs) were measured in all the neonates at 3,6,9,and 12 months after birth;clinical curative effect and prognosis were compared between the two groups.Results:The improvement time of respiration,the disappearance times of convulsion,symptoms,and signs in treatment group were shorter than those in control group;the incidence of sequelae in treatment group was lower than that in control group,NBNA score and DQ in treatment group were higher than those in control group,there was statistically significant difference in the above-mentioned indexes between the two groups(P<0.01).Conclusion:Compared with cytidine diphosphate choline,the total effective rate of monosialotetrahexosylganglioside sodium salt injection was improved for treatment of neonates with moderate and severe HIE,convulsion was easy to be controlled,the symptoms and signs of nervous system recovered rapidly,such as disturbance of consciousness and muscular tension,the effect on improving prognosis was dominant,the method can reduce the incidence of sequelae and neonatal mortality,have no adverse reactions,which is worthy to be popularized and applied in clinic.