| 丁酸盐与非甾体抗炎药对大肠腺瘤和腺癌细胞的抗增殖作用 |
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| 引用本文： | 张志宏,欧阳钦,甘华田. 丁酸盐与非甾体抗炎药对大肠腺瘤和腺癌细胞的抗增殖作用[J]. 四川大学学报(医学版), 2003, 34(3): 544-545,593 |
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| 作者姓名： | 张志宏 欧阳钦 甘华田 |
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| 作者单位： | 四川大学华西医院,消化内科,成都,610041 |
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| 基金项目： | 四川省科技厅重点课题 (编号 174)资助 |
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| 摘 要： | 目的：观察丁酸盐和两种非甾体药物(NSAIDs)阿斯匹林和高选择性环氧合酶-2(COX-2)抑制剂NS-398对原代培养的大肠腺瘤细胞和HT-29腺癌细胞抗增殖作用的影响，并探讨其可能的作用机制．方法用MTT法检测各药物对两种细胞的抗增殖作用。结果：三种药物均可起到抑制细胞增殖的作用；丁酸盐和两种NSAIDs的联用可不同程度的增强其作用。结论：单用丁酸盐和两种NSAIDs均有抗增殖的作用，两者联用可使其疗效增强．
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| 关 键 词： | 丁酸盐 非甾体抗炎药 大肠腺瘤 腺癌细胞 抗增殖作用 |
Effects of NaBT and NSAIDs on Colorectal Adenoma-Carcinoma Cells |
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| Zhang Zhihong,Ouyang Qin,Gan Huatian. Effects of NaBT and NSAIDs on Colorectal Adenoma-Carcinoma Cells[J]. Journal of Sichuan University. Medical science edition, 2003, 34(3): 544-545,593 |
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| Authors: | Zhang Zhihong Ouyang Qin Gan Huatian |
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| Affiliation: | Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China. |
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| Abstract: | Objective We investigated the primary adenoma cells and HT-29 cells in an attempt to know whether NaBT and two NSAIDs (aspirin and NS-398) could be used as effective adjuvant for reducing cell proliferation, and to explore the possible mechanisms therein involved. Methods MTT was employed in detecting the anti-proliferative effects on both adenoma and HT-29 culture cells. Results Both butyrate and NSAIDs could inhibit the proliferation of cells. The effects of the NSAIDs could be synergistically strengthened by combining with butyrate. Conclusion NaBT and the two NSAIDs could inhibit the cell proliferation when used separately, and a combination of butyrate with aspirin or NS-398 could enhance the inhibitory effects. |
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| Keywords: | Chemoprevention NaBT NSAIDs Apoptosis |
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