| 一氧化氮治疗急性坏死性胰腺炎的实验研究 |
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| 引用本文： | 刘牧林,郑士友,方先业.一氧化氮治疗急性坏死性胰腺炎的实验研究[J].蚌埠医学院学报,2001,26(2):95-96. |
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| 作者姓名： | 刘牧林 郑士友 方先业 |
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| 作者单位： | 蚌埠医学院附属医院 急诊外科, |
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| 基金项目： | 安徽省教育厅资助课题(97JL152) |
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| 摘 要： | 目的：探讨一氧化氮（NO）的前体物质精氨酸治疗急性坏死性胰腺炎的机制。方法：120只大鼠随机分为胰腺炎对照组（A组）、精氨酸治疗组（B组）和精氨酸抑制剂治疗组（C组）；观察其血清磷脂酶A2（PLA2）、肿瘤坏死因子（TNF）、NO含量计算各组腹水量、24h病死率和平均生存时间。结果：B组PLA2和TNF较A、C两组低（P＜0.01），NO含量较A、C两组高（P＜0.01），24h病死率较低，平均生存时间长，病理损害较轻。结论：NO对急性坏死性胰腺炎有一定的保护作用。
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| 关 键 词： | 急性坏死性胰腺炎 一氧化氮 精氨酸 治疗 |
| 文章编号： | 1000-2200(2001)02-0095-02 |
| 修稿时间： | 2000年3月20日 |
Experimental study of nitric oxide in treatment of acute hemorrhagic necrotizing pancreatitis |
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| LIU Mu lin,ZHENG Shi you,FANG Xian ye.Experimental study of nitric oxide in treatment of acute hemorrhagic necrotizing pancreatitis[J].Journal of Bengbu Medical College,2001,26(2):95-96. |
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| Authors: | LIU Mu lin ZHENG Shi you FANG Xian ye |
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| Abstract: | Objective:To study the mechanism of nitric oxide(NO) donors arginine in treatment of acute hemorrhagic necrotizing pancreatitis(AHNP).Methods:One hundred and twenty SD rats were divided into 3 groups .Group A was treated with NS,Group B with L arginine and group C with L arginine inhibitors.Results:The rats in group B exhibited a low degree of PLA\-2 and TNF,a high degree of NO( P <0.01) and the mortality was much lower than that in group A and C.The rats in group B had a longer survival time and less histologic damage than the rats in group A and C.Conclusions:All the results suggest that NO has preventive effect on AHNP. |
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| Keywords: | pancreatitis nitric oxide arginine |
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