| YN-PTOL对O_3衰老模型自由基损伤的保护作用 |
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| 引用本文： | 陈友琴,胡新珉,刘鸿莲,幸浩洋.YN-PTOL对O_3衰老模型自由基损伤的保护作用[J].中国医学物理学杂志,2000(1). |
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| 作者姓名： | 陈友琴 胡新珉 刘鸿莲 幸浩洋 |
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| 作者单位： | 华西医科大学基础医学院物理教研室!四川 成都 610044 |
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| 摘 要： | 本研究通过建立的臭氧（Ｏ３）致衰老的小鼠模型，采用改良硫代巴比妥酸荧光法，观察了云南花粉田七口服液（ＹｕｎＮａｎ Ｐｏｌｌｅｎ Ｔｉｅｎｃｈｉ Ｏｒａｌ Ｌｉｑｕｉｄ，简称 ＹＮ－ＰＴＯＬ）预处理对血浆和心肌中脂质过氧化物（Ｌｉｐｉｄ Ｐｅｒｏｘｉｄｅ， ＬＰＯ）含量的影响。结果表明：预处理实验组ＬＰＯ含量明显低于空白对照组和阳性对照组（Ｐ＜０．０５），但空白对照组与阳性对照组相比，差别无显著性意义（Ｐ＞０．０５）。这表明：ＹＮ－ＰＴＯＬ预处理对Ｏ_3致衰老小鼠模型的自由基损伤具有明显保护作用，是一种预防与治疗 Ｏ３损伤的有效药物。
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| 关 键 词： | 脂质过氧化物 臭氧 衰老 预处理 |
Protective effect of preconditioning with yunnan pollen tienchi oral liquid on free radical injury in mouse |
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| CHEN You-qin,HU Xin-min,LIU Hong-liang,XI Hao-yan.Protective effect of preconditioning with yunnan pollen tienchi oral liquid on free radical injury in mouse[J].Chinese Journal of Medical Physics,2000(1). |
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| Authors: | CHEN You-qin HU Xin-min LIU Hong-liang XI Hao-yan |
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| Abstract: | To determine whether preconditioning with YunNan Pollen Tienchi Oral Liquid (YN-PTOL) has protective effect, a model of aging was produced in mouse by inspiring an quantities Ozone (O3). Lipid peroxide (LPO) of plasma and myocardium was measured by the thinobarbituric acid (TBA) fluorescence spectrophotometry method. The result showed that the amount of LPO in the experimental group can be highly decreased than the blank group and the positive group(p<0. 05), but no significant difference between the blank group and the positive group (P>0. 05). The study indicated the preconlitioning with YN-PTOL protects the mouse from free radical injury. |
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| Keywords: | lipid peroxide ozone aging preconditioning |
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