注射用埃索美拉唑治疗消化性溃疡大出血的疗效分析

目的比较注射用埃索美拉唑与注射用奥美拉唑对消化性溃疡大出血的疗效、不良反应及成本-效果比。方法选择因消化性溃疡大出血的住院病例64例,随机分为埃索美拉唑组(30例)及奥美拉唑组(34例)。分别给予埃索美拉唑或奥美拉唑静脉推注,依据出血停止的判断标准,比较两组患者出血停止的时间,并记录两组病人发生不良反应的情况。运用药物经济学方法分析两组间成本-效果比。结果埃索美拉唑组显效率76.67%,奥美拉唑组显效率50%(χ2=4.836 P=0.028)。埃索美拉唑组总有效率90%,奥美拉唑组总有效率79.41%(χ2=0.671 P=0.413)。两组中不良反应以恶心为主,发生率分别为3.33%、2.94%(P=1.0)。成本-效果比分别为33.58、35.56。结论注射用埃索美拉唑是治疗消化性溃疡大出血既有效、安全又经济的药物。

The Efficacy of Intravenous Esomeprazole in the Treatment of Peptic Ulcer Bleeding.

Objective To compare the efficacy,adverse reaction and cost-effectiveness between intravenous Esomeprazole(Nexium) and intravenous Omerazole(Losec) in the treatment of peptic ulcer bleeding.Methods Sixty-four patients with upper peptic ulcer bleeding were randomly divided into Esomeprazole group(n=30) and Omerazole group(n=34).According to the criteria for bleeding stop,the time to stop bleeding was compared and adverse reaction recorded in both groups.Pharmacoeconomics method was used to analyze the cost-effectiveness ratio between the two groups.Results The significant efficiency rate was 76.67% in Esomeprazole group and 50% in Omerazole group(χ2=4.836 P=0.028).The total effective rate was 90% in Esomeprazole and 79.41% in Omerazole group(χ2=0.671 P=0.413).Nausea was the main adverse reaction in both groups,the incidence rate was 3.33% and 2.94% respectively(P=1.00).The cost-effectiveness ratio(C/E) was 33.58 and 35.56 respectively.Conclusions Intravenous Esomeprazole is effective,safe and low-cost for peptic ulcer bleeding.