Molecular typing and characterization of extended-spectrum TEM, SHV and CTX-M beta-lactamases in clinical isolates of Enterobacter cloacae |
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| Authors: | Biendo Maurice Manoliu Claudia Laurans Geneviève Castelain Sandrine Canarelli Brigitte Thomas Danièle Hamdad Farida Rousseau Florence Eb François |
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| Institution: | Service de Bactériologie, CHU Nord, Place Victor Pauchet, 80054 Amiens Cedex 1, France. Biendo.Maurice@chu-amiens.fr |
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| Abstract: | Sixty-one non-repetitive Enterobacter cloacae ESBL producers were collected at the Amiens University Hospital in France. Eight beta-lactam resistance phenotypes (a-h) and three aminoglycoside resistance phenotypes (i-k) were identified among these isolates, and 32 different pulsotypes were observed. Of these 61 isolates, 37 were sequenced and found to harbor beta-lactamases with a pI of 5.9 (TEM-4), 6.5 (TEM-24), 7.8 (SHV-4), 8.2 (SHV-12), 8.4 (CTX-M-1) and 8.0 (CTX-M-9). Four imipenem-resistant ESBL-producing E. cloacae isolates did not express the 38kDa OMP, indicating that this resistance is associated with porin deficiency. |
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