| 玉米苞叶煎剂对高脂大鼠血清NO ET水平及内皮凋亡的作用 |
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| 引用本文： | 甄艳军,侯建明,姜秀娟,丁涛,张东辉,曹华. 玉米苞叶煎剂对高脂大鼠血清NO ET水平及内皮凋亡的作用[J]. 辽宁中医杂志, 2009, 0(2): 307-308 |
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| 作者姓名： | 甄艳军 侯建明 姜秀娟 丁涛 张东辉 曹华 |
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| 作者单位： | 河北医科大学基础课教学部; |
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| 基金项目： | 河北省中医药管理局计划项目(200108) |
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| 摘 要： | 目的:观察玉米苞叶煎剂对食饵性高血脂大鼠主动脉内皮细胞凋亡的干预作用及血清NO、ET水平的影响。方法:选用雄性SD大鼠,随机分为正常对照、病理模型、阳性对照及玉米苞叶煎剂组。复制食饵性AS早期模型,同时给予玉米苞叶煎剂预防性给药,以吉非罗齐为阳性药对照。实验9周,检测血清脂质,NO和ET,流式细胞术定量检测主动脉内皮细胞凋亡率及增殖指数。结果:玉米苞叶煎剂组TC、TG、VLDL较模型组显著降低(P<0.05);内皮细胞凋亡率较模型组明显下降(P<0.05),增殖指数轻度上升(P>0.05);血清ET下降(P>0.05),NO上升(P>0.05)。结论:玉米苞叶煎剂可调节高脂大鼠血清NO和ET水平,降低内皮凋亡率,促进内皮修复。
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| 关 键 词： | 玉米苞叶 大鼠 高脂血症 内皮 凋亡 |
Effect of Corn Bract on the Level of NO,ET and Apoptosis of Endothelial Cells |
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| ZHEN Yan-jun,HOU Jian-ming,JIANG Xiu-juan,DING Tao,ZHANG Dong-hui,CAO Hua. Effect of Corn Bract on the Level of NO,ET and Apoptosis of Endothelial Cells[J]. Liaoning Journal of Traditional Chinese Medicine, 2009, 0(2): 307-308 |
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| Authors: | ZHEN Yan-jun HOU Jian-ming JIANG Xiu-juan DING Tao ZHANG Dong-hui CAO Hua |
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| Affiliation: | The Basic Teaching Department of Hebei Medical University;Shijiazhuang 050091;Hebei;China |
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| Abstract: | Objective:To study the effect of corn bract on the level of NO,ET and apoptosis of endothelial cells.Methods:Male Sprague-Dawley rats were randomly divided into control and pathological model,the positive control group and the decoction of corn bract.Early Atheros-clerotic models of hyperlipemia were developed by feeding the SD rats with high-cholesterol-fat diet and the decoction of corn bract were administrated to the rats at the same time.The blood-fat,NO and ET were measured after nine weeks,the rate of... |
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| Keywords: | Corn bract Rat Hyperlipidemia Endothelial cell Apoptosis |
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