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The Dilemma of Chronic Recurrent Multifocal Osteomyelitis
Institution:1. Children and Adolescence Unit, Royal National Orthopaedic Hospital, Stanmore, UK;2. Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George''s, University of London, UK;1. Faculdade de Medicina-Universidade do Porto, Porto, Portugal;2. Pneumology Department and Diffuse Lung Disease Study Group/Centro Hospitalar Universitário de São João, Porto, Portugal;3. Oficina de Biostatística, Ermesinde, Portugal;4. Radiology Department and Diffuse Lung Disease Study Group/ Centro Hospitalar Universitário de São João, Porto, Portugal;5. Pathology Department and Diffuse Lung Disease Study Group/ Centro Hospitalar Universitário de São João, Porto, Portugal;1. Istinye University Faculty of Medicine, LIV Hospital, Department of Rheumatology, Turkey;2. Medicalpark Hospital, Department of Chest Diseases, Turkey;3. Ege University Faculty of Medicine, Department of Internal Medicine, Turkey;4. Ege University Faculty of Medicine, Department of Statistics, Turkey;1. Rheumatology & Rehabilitation Department, Zagazig University, Zagazig, Egypt;2. Rheumatology and Rehabilitation Department, Cairo University, Cairo, Egypt;1. Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;2. Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;3. Department of Hematology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;1. Servicio de Dermatología, Hospital Universitari Sagrat Cor, Barcelona, España;2. Servicio de Anatomía Patológica, Hospital Universitari Sagrat Cor, Barcelona, España
Abstract:Chronic recurrent multifocal osteomyelitis (CRMO) is a rare idiopathic inflammatory disease that affects mainly children and young adults, resulting in significant morbidity especially if not diagnosed early. The clinical signs and symptoms are nonspecific, with a consequential delay in diagnosis. Radiological and histopathological criteria are important for its definition. Two cases of CRMO are reported, highlighting the diagnostic challenge and demonstrating the importance of timely investigations.
Keywords:Chronic recurrent multifocal osteomyelitis  Bone pain  Children  Osteomyelitis  Osteomielitis multifocal recurrente crónica  Dolor de huesos  Niños  Osteomielitis
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