Adiposity and Endometriosis Severity and Typology |
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| Institution: | 1. Department of Family and Preventive Medicine, Division of Public Health (Ms. Byun and Drs. Stanford, Allen-Brady, and Schliep);2. Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility (Drs. Peterson and Taylor), University of Utah, Salt Lake City, Utah;3. Department of Nursing & Healthcare Leadership, University of Washington Tacoma, Tacoma (Dr. Backonja);4. Department of Biomedical Informatics & Medical Education, University of Washington School of Medicine, Seattle (Dr. Backonja), Washington;5. Department of Internal Medicine, Genetic Epidemiology (Dr. Allen-Brady);6. Department of Family and Consumer Studies and Population Sciences/Huntsman Cancer Institute (Dr. Smith), University of Utah, Salt Lake City, Utah;7. Dean''s Office, College of Health and Human Services, George Mason University, Fairfax, Virginia (Dr. Buck Louis).;1. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Gyeonggi-do (Dr. Ju-Hyun Kim);2. Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Gwangjin-gu (Dr. Shim);3. Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Songpa-gu (Drs. Nam, Lee, Park, D. Y. Kim, Suh, Jong-Hyeok Kim, Y. M. Kim, and Y. T. Kim), Seoul, Korea.;1. Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Sydney, New South Wales, Australia;2. Department of Obstetrics and Gynecology, McMaster University, Hamilton, Canada;1. Department of Obstetrics and Gynecology, Barzilai University Medical Center, Ashkelon, and Faculty of Health Sciences, Ben-Gurion University of Negev, Beer-Sheva (Dr. Namazov), Israel;2. Women''s Centre, Oxford University Hospital, Oxford (Dr. Kathurusinghe), United Kingdom;3. Endometriosis Center, Clinique Tivoli-Ducos, Bordeaux (Drs. Marabha, Merlot, Forestier, and Roman);4. Department of Gynecology and Obstetrics (Dr. Hennetier);5. Department of Digestive Surgery (Dr. Tuech), Rouen University Hospital, Rouen, France;6. Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus (Dr. Roman), Denmark. |
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| Abstract: | Study ObjectivePrior research has collectively shown that endometriosis is inversely related to women's adiposity. The aim of this study was to assess whether this inverse relationship holds true by disease severity and typology.DesignCross-sectional study among women with no prior diagnosis of endometriosis.SettingFourteen clinical centers in Salt Lake City, UT, and San Francisco, CA.PatientsA total of 495 women (of which 473 were analyzed), aged 18–44 years, were enrolled in the operative cohort of the Endometriosis, Natural History, Diagnosis, and Outcomes (ENDO) Study.InterventionsGynecologic laparoscopy/laparotomy regardless of clinical indication.Measurements and Main ResultsParticipants underwent anthropometric assessments, body composition measurements, and evaluations of body fat distribution ratios before surgery. Surgeons completed a standardized operative report immediately after surgery to capture revised American Society for Reproductive Medicine staging (I–IV) and typology of disease (superficial endometriosis SE], ovarian endometrioma OE], and deep infiltrating endometriosis DIE]). Linear mixed models, taking into account within-clinical-center correlation, were used to generate least square means (95% confidence intervals) to assess differences in adiposity measures by endometriosis stage (no endometriosis, I–IV) and typology (no endometriosis, SE, DIE, OE, OE + DIE) adjusting for age, race/ethnicity, and parity. Although most confidence intervals were wide and overlapping, 3 general impressions emerged: (1) women with incident endometriosis had the lowest anthropometric/body composition indicators compared with those without incident endometriosis, (2) women with stage I or IV endometriosis had lower indicators compared with women with stage II or III, and (3) women with OE and/or DIE tended to have the lowest indicators, whereas women with SE had the highest indicators.ConclusionOur research highlights that the relationship between women's adiposity and endometriosis severity and typology may be more complicated than prior research indicates. |
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