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Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages
Authors:Mengyang Liu  Barbara Maurer  Boris Hermann  Behrooz Zabihian  Michelle G Sandrian  Angelika Unterhuber  Bernhard Baumann  Edward Z Zhang  Paul C Beard  Wolfgang J Weninger  Wolfgang Drexler
Abstract:Chick embryos are an important animal model for biomedical studies. The visualization of chick embryos, however, is limited mostly to postmortem sectional imaging methods. In this work, we present a dual modality optical imaging system that combines swept-source optical coherence tomography and whole-body photoacoustic tomography, and apply it to image chick embryos at three different development stages. The explanted chick embryos were imaged in toto with complementary contrast from both optical scattering and optical absorption. The results serve as a prelude to the use of the dual modality system in longitudinal whole-body monitoring of chick embryos in ovo.OCIS codes: (170.4500) Optical coherence tomography, (170.5120) Photoacoustic imaging, (170.3880) Medical and biological imaging
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