Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population |
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| Institution: | 1. Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 570102, Hainan, China;2. Department of General Practice, Hainan General Hospital, Haikou 570311, Hainan, China;3. Department of General Practice, The Second Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan, China;4. Hainan General Hospital, University of South China, Haikou 570311, Hainan, China;5. Department of Emergency, Hainan General Hospital, Haikou 570311, Hainan, China;1. Unidad de Neumología, Agencia Sanitaria Costa del Sol, Marbella, Málaga, Spain;2. Servicio de Neumología, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain;1. Department of Radiology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey;2. Department of Radiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey;1. Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain;2. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain;3. Grupo NeumoVigo I+i, Instituto de Investigación Sanitaria Galicia Sur (IISGS), Servicio de Neumología, Hospital Álvaro Cunqueiro, Vigo, Pontevedra, Spain;4. Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Seville, Spain;5. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain;1. Pneumology Department, Hospital Universitario i Politécnico La Fe, Valencia, Spain;2. Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy;3. University of Milan, Department of Pathophysiology and Transplantation, Milan, Italy;4. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Respiratory Unit and Cystic Fibrosis Adult Center, Milan, Italy;1. Servicio de Neumología, Hospital Clínico Universitario, INCLIVA, Valencia, Spain;2. UGCMQ de enfermedades respiratorias, Hospital Regional Universitario de Málaga, Málaga, Spain;3. Unidad Especializada en Tabaquismo, Hospital Clínico San Carlos, Madrid, Spain;1. Presidente de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR), Spain;2. Director del Programa de Investigación Integrada en Tabaquismo, SEPAR, Spain;3. Coordinador del Área de Tabaquismo, SEPAR, Spain |
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| Abstract: | IntroductionCytochrome P450 (CYP) 2J2 is a major enzyme that controls epoxyeicosatrienoic acids biosynthesis, which may play a role in chronic obstructive pulmonary disease (COPD) development. In this study, we aimed to assess the influence of CYP2J2 polymorphisms with COPD susceptibility.Material and methodsA case–control study enrolled 313 COPD cases and 508 controls was to investigate the association between CYP2J2 polymorphisms and COPD risk. Agena MassARRAY platform was used to genotype CYP2J2 polymorphisms. Odds ratios (OR) and 95% confidence intervals (CI) were calculated to evaluate the association between CYP2J2 polymorphisms and COPD risk.ResultsWe observed rs11207535 (homozygote: OR = 0.08, 95%CI = 0.01–0.96, p = 0.047; recessive: OR = 0.08, 95%CI = 0.01–0.94, p = 0.044), rs10889159 (homozygote: OR = 0.08, 95%CI = 0.01–0.92, p = 0.043; recessive: OR = 0.08, 95%CI = 0.01–0.90, p = 0.040) and rs1155002 (heterozygote: OR = 1.63, 95%CI = 1.13–2.36, p = 0.009; dominant: OR = 1.64, 95%CI = 1.15–2.35, p = 0.006; additive: OR = 1.45, 95%CI = 1.09–1.92, p = 0.011) were significantly associated with COPD risk. Allelic tests showed T allele of rs2280274 was related to a decreased risk of COPD and T allele of rs1155002 was associated with an increased COPD risk. Stratified analyses indicated the effects of CYP2J2 polymorphisms and COPD risk were dependent on gender and smoking status (p < 0.05). Additionally, two haplotypes (Ars11207535Crs10889159Trs1155002 and Ars11207535Crs10889159Crs1155002) significantly decreased COPD risk.ConclusionIt suggested CYP2J2 polymorphisms were associated with COPD susceptibility in the Chinese Han population. |
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| Keywords: | Chronic obstructive pulmonary disease Genetic polymorphism Enfermedad pulmonar obstructiva crónica Polimorfismo genético |
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