西酞普兰与丙咪嗪治疗抑郁症对照研究

目的：比较西酞普兰与丙咪嗪治疗抑郁症的疗效及安全性。方法：将77例抑郁症患者随机分为两组，分别为西酞普兰组（41例）与丙咪嗪组（36例），疗程6周。用汉密尔顿抑郁量表（HAMD）及汉密尔顿焦虑量表（HAMA）在治疗前及治疗后2、4、6周评定疗效；用副反应量表（TESS）评定不良反应。结果：西酞普兰组显效率70．73％、有效率85．36％，丙咪嗪组显效率75．0％、有效率86．11％，两组间差异无显著性（P〉0．05）；不良反应方面，西酞普兰出现不良反应18例，丙眯嗪出现25例，两组间差异有显著性（P〈0．01）。结论：西酞普兰是治疗抑郁症较为安全有效的药物。

A comparative study of citalopram and imipramine in the treatment of depressive disorders

Objective:To compare the clinic effects and the safety of citalopram and imipramine in treatment of depression.Methods:Seventy seven patients with depressive disorder were randomly divided into citalopram treatment(41 patients)and imipramine treatment(36 patients)for 6 weeks.The clinic effects and side effects were tested with HAMD,HAMA and TESS before treatment and 2,4,6 weeks after treatment respectively.Results: After 6-week treatment,the significant improvement rate and response rate was 70.73% and 85.36% respectively in citalopram group,75.0% and 86.11% respectively in imipramine group.There were no significant differences between two groups(P>0.05).18 patients had the side effects in citalopram group and 25 ones in imipramine group.There was statistically difference between two groups(P<0.01).Conclusions: Citalopram has better efficacy and fewer side effects for depressive disorders.