高血压肾脏微循环功能障碍检测研究进展

高血压与肾脏关系密切。肾脏微循环结构独特,呈球囊形网状结构微血管网,易受高压力、高灌注的影响。其变化可以反映早期肾功能状态,故检测肾脏微循环对高血压肾病的诊断、治疗和预后具有积极的意义。通过检测尿液中的微量清蛋白、转铁蛋白、β2微球蛋白、α1微球蛋白、视黄醇结合蛋白、清蛋白/肌酐、N-乙酰-β氨基葡萄糖苷酶和血清中的尿酸、胱抑素及超声多普勒肾血流测定、放射性核素肾显像等手段可以有效地反映肾脏微循环功能。

Research Progress of Test for Renal Microcirculation Function Disorder Caused by Hypertension

Hypertensive disease was closely related to kidney.Because the structure of renal microcirculation has an unique balloon-shaped reticular formation,it was susceptible to high pressure and perfusion,The change may reflect early renal function,so detection of renalmicrocirculation had positive significance to the diagnosis,treatment and prognosis of hypertensive kidney disease.By testing urine albumin,transferrin,β2-microalbumin,α1-microalbumin,retinol binding protein,albumin/creatinine,N-acetyl-β-glucosaminidase,serum uric acid,cystatin,measurement of ultrasound Doppler renal blood flow,radionuclide renal imaging and other means can effectively reflect the renal microcirculation.