| Shh蛋白在前列腺癌组织中的表达及临床意义 |
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| 引用本文： | 张爱建,刘孝东,陈剑珩,张建华,申吉泓. Shh蛋白在前列腺癌组织中的表达及临床意义[J]. 西部医学, 2013, 25(6): 846-848 |
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| 作者姓名： | 张爱建 刘孝东 陈剑珩 张建华 申吉泓 |
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| 作者单位： | 昆明医科大学第一附属医院泌尿外科,云南昆明,650032 |
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| 基金项目： | 云南省科技厅联合专项课题 |
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| 摘 要： | 目的探讨Shh蛋白在人前列腺癌、前列腺增生组织中的表达及意义。方法采用免疫组化法检测60例前列腺癌和60例前列腺增生组织Shh的表达。结果 Shh在前列腺增生组织中不表达或低表达,而在前列腺癌组织中的表达明显高于增生组织,前列腺癌中Shh的表达与病理分级密切相关。结论 Hedgehog信号通路中Shh蛋白表达上调可能参与了前列腺癌的发病,其在前列腺癌的发生、发展等方面可能具有重要作用。
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| 关 键 词： | 前列腺癌 Shh 免疫组化 |
Expression and significance of Shh in prostate cancer |
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| Affiliation: | ZHANG Ai-jian ,LIU Xiao-dong ,CHEN Jian-heng ,et al (Department of Urology, The First Affiliated Hospital ,Kunming Medical University ,Kunming 650031 ,Yunnan ,China) |
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| Abstract: | Objective To explore the expression and significance of Shh in prostate cancer and benign prostatic hy- perplasia. Methods 60 cases of prostate cancer and 60 cases of benign prostatic hyperplasia were studied by immunohisto- chemisty using the Shh antibody. Results Shh was not expressed or seldom expressed in benign prostatic hyperplasia,Up - regulation of Shh was more obviously expressed in prostate cancer than in benign prostatic hyperplasia. The increased Shh level was significantly correlated with pathological grades. Conclusion Up - regulation of Shh in Hedgehog signaling pathway might get involved in prostate cancer, and it might do a lot in the course of developing and progressing prostate cancer. |
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| Keywords: | Prostate cancer Shh Immunohistochemistry |
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