布地奈德联合特布他林与氨溴索雾化吸入治疗AECOPD患者临床疗效观察

目的探讨布地奈德混悬液联合特布他林、氨溴索雾化吸入治疗急性加重期慢性阻塞性肺疾病(AECO-PD)患者的临床疗效。方法选择呼吸内科AECOPD患者96例,按入院先后顺序分为治疗组和对照组各48例,两组患者均给予持续低流量吸氧、抗感染、化痰止咳、、维持水电解质酸碱平衡及营养支持等常规治疗。治疗组在常规治疗基础上给予布地奈德混悬液联合特布他林、氨溴索雾化吸入治疗;对照组在常规治疗基础上给予布地奈德混悬液吸入治疗,比较两组临床疗效、血气分析和肺功能结果。结果治疗组总有效率95.8%,对照组总有效率75.0%,两组比较差异有统计学意义(P<0.05),血气指标(PaO2、PaCO2)和肺功能指标(FEV1、FVC)两组组内治疗前后比较均有明显改善,差异有统计学意义(P<0.05),治疗组与对照组治疗后比较治疗组改善明显,差异有统计学意义(P<0.05),治疗组无明显不良反应。结论布地奈德联合特布他林、氨溴索雾化吸入治疗急性加重期慢性阻塞性肺疾病患者疗效肯定,无明显不良反应,值得临床推广应用。

Clinical observation of budesonide combined with terbutaline and ambroxol atomized inhalation on acute exacerbation of chronic obstructive pulmonary disease

Objective To explore the clinical effect of aerosol inhalation of budesonide combined with terbutaline and ambroxol in treatment of the patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods 96 cases patients of pneumology department with AECOPD in our hospital were divided into theatmenl group and control group according to the order of admission, each group was 48 eases. Both groups of patients were given con- ventional therapy including continuous low flow oxygen, antibiotics, phlegm and cough, nutritional support, and maintai- ning water and electrolyte acid-base balance. On the basis of conventional therapy, the treatment group received budes- onide combined with terbutaline and ambroxol atomized inhalation, the control group only received budesonide. The clini- cal effieacy, blood gas analysis and the results of pulmonary function of two groups were observed and compared. Results The total efficiency of treatment group was 95.8~ and the control group was 75.0~, the difference was significant between two groups （P〈0. 05）. Either index of the blood （PaO2, PaCOz） or pulmonary function （FEV1, FVC） showed improved apparently within the group before and after treatment with the difference of statistical significance （P~0. 05）, the treatment group has ameliorate obviously at after treatment compare with control group and the difference was signifi- cant （P〈0. 05）. It was no found significant adverse reaction during the treatment. Conclusion Budesonide combined with terbutaline and ambroxol atomized inhalation in treatment of the patients with AECOPD was effective, litter side effect, and it is worthy of clinical application.