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Hepatic clearance of local anesthetics in man |
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| Authors: | Geoffrey T. Tucker Lars Wiklund Anita Berlin-Wahlen Laurence E. Mather |
| Affiliation: | (1) Section of Therapeutics, Academic Division of Medicine, University of Sheffield, The Royal Infirmary, S6 3DA Sheffield, UK;(2) Department of Anaesthesiology, Akademiska Sjukhuset Uppsala, Uppsala, Sweden;(3) Astra Läkemedel AB, Södertalje, Sweden;(4) Flinders Medical Centre, Unit of Anaesthesia and Intensive Care, 5042 Bedford Park, SA, Australia |
| Abstract: | Two independent methods of calculating hepatic drug clearance were applied to data from studies of the human pharmacokinetics of lidocaine, bupivacaine, and etidocaine. Within experimental limitations, agreement was good between estimates obtained by measurement of areas under blood drug concentration-time curves after rapid intravenous injection and by direct measurement of arterial and hepatic venous drug concentrations. Apparent hepatic extraction ratios of the agents followed the order etidocaine ( 0.73)/s>lidocaine (0.68>bupivacaine (0.37).Pharmacokinetic implications of increases in hepatic blood flow induced by the agents are discussed. |
| Keywords: | hepatic clearance extraction ratio local anesthetics pharmacokinetics lidocaine bupivacaine etidocaine cardiovascular effects of local anesthetics |
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