| 大鼠短暂性局灶性脑缺血后侧脑室室下带神经细胞再生的观察 |
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| 引用本文： | 周建平,顾振,马瑞,韩群颖,赵珺,施韬. 大鼠短暂性局灶性脑缺血后侧脑室室下带神经细胞再生的观察[J]. 南京医科大学学报(自然科学版), 2003, 23(4): 335-337,T001 |
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| 作者姓名： | 周建平 顾振 马瑞 韩群颖 赵珺 施韬 |
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| 作者单位： | [1]南京医科大学解剖学与组织胚胎学系，江苏南京210029 [2]南京医科大学第一附属医院麻醉科，江苏南京210029 |
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| 基金项目： | 南京医科大学科技发展基金资助项目(NY02063) |
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| 摘 要： | 目的：观察大鼠短暂性局灶性脑缺血后侧脑室嘴侧的室下带(SVZ)神经细胞再生的时间规律。方法：行线栓法制作局灶性脑缺血模型，用BrdU标记再生的神经细胞，再用免疫组织化学SP法检测含BrdU的细胞。观察短暂性局灶性脑缺血后1、4、7、10、14天SVZ神经细胞再生的数量。结果：缺血后4天BrdU阳性细胞明显增加，7天时达到峰值，随后开始下降，在14天时明显下降，但仍高于正常组。结论：短暂性局灶性脑缺血可促进室下带的神经细胞再生，提示脑有自我修复的潜在能力。
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| 关 键 词： | 脑缺血 神经再生 室下带 大鼠 |
| 文章编号： | 1007-4368(2003)04-0335-03 |
The Observation of Neurogenesis in the Subventricular Zone in Rats after Transient Fo- cal Cerebral Ischemia |
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| ZHOU Jian-ping,GU Zhen,MA Rui,HAN Qun-ying,ZHAO Jun,SHI Tao. The Observation of Neurogenesis in the Subventricular Zone in Rats after Transient Fo- cal Cerebral Ischemia[J]. Acta Universitatis Medicinalis Nanjing, 2003, 23(4): 335-337,T001 |
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| Authors: | ZHOU Jian-ping GU Zhen MA Rui HAN Qun-ying ZHAO Jun SHI Tao |
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| Abstract: | Objective: To observe the regularity of transient focal cerebral ischemia and neurogenesis of subventricular zone. Methods: Use middle cerebral artery occlusion (MCAO)to make focal cerebral ischemia model. BrdU, the thymidine analog that can incorporated into the DNA during the S phase of the cell cycle. Investigate the numbers of neurogenesis in the SVZ at 1, 4, 7, 10, 14 days after transient focal cerebral ischemia. Results: There was a significant increase in the numbers of BrdU immunoreactive cells in sub-ventricular zone at 4 days and with a peak at 7 days, then the numbers started to decease, but were still more than normal. Conclusion: Transient focal cerebral ischemia may enhance the neurogenesis of the subventricular zone and suggest that the cerebral has self-renovated capacity. |
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| Keywords: | cerebral ischemia neurogenesis subventricular zone rat |
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