| 自发性高血压大鼠组织和心肾缺血组织中Na~＋／Ca~（2＋）交换体基因的表达 |
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| 引用本文： | 王瑜,杨鸿,张晨晖,汤健.自发性高血压大鼠组织和心肾缺血组织中Na~＋／Ca~（2＋）交换体基因的表达[J].北京大学学报(医学版),1994(Z1). |
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| 作者姓名： | 王瑜 杨鸿 张晨晖 汤健 |
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| 作者单位： | 北京医科大学心血管研究所 |
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| 摘 要： | 自发性高血压和心肾缺血组织中钙离子水平明显升高。为探讨Ｎａ＋／Ｃａ２＋交换体在其中的作用，我们应用半定量逆转录一多聚酶链反应（ＲＴ一ＰＣＲ）技术，比较了自发性高血压大鼠（ＳＨＲ）部分组织、缺血时心肌和肾脏与其正常对照组织中Ｎａ＋／Ｃａ２＋交换体ｍＲＮＡ的水平。结果表明，ＳＨＲ所测组织中Ｎａ＋／Ｃａ２＋交换体ｍＲＮＡ较正常ＷＫＹ大鼠均降低。结扎４８小时引起的缺血肾脏Ｎａ＋／Ｃａ２＋交换体ｍＲＮＡ亦降低。而因异丙基肾上腺素引起的心肌缺血组织中，Ｎａ＋／Ｃａ２＋交换体基因的表达上升。
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| 关 键 词： | Na＋／Ca2＋交换体基因，自发性高血压，心肾缺血 |
THE GENE EXPRESSION OF NA+/CA2+EXCHANGER IN SPONTANEOUSLY
HYPERTENSIVE RATS AND ISCHEMIC HEART AND KIDNEY |
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| Institute of
Cardiovascular Research Wang Yu,et al.THE GENE EXPRESSION OF NA+/CA2+EXCHANGER IN SPONTANEOUSLY
HYPERTENSIVE RATS AND ISCHEMIC HEART AND KIDNEY[J].Journal of Peking University:Health Sciences,1994(Z1). |
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| Authors: | Institute of
Cardiovascular Research Wang Yu |
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| Abstract: | ntracellular Ca2+
concentration increases significantly in spontaneously hypertensive
rats(SHR ) and is-chemic tissues.In order to evaluate the
significance of Na+/Ca2+exchanger in these diseases,we detected the
gene expression of Na+/Ca2+ exchanger in some tissues of SHR and
ischemic heart and kidney, and compared them with their normal
controls. The results showed that in SHR and ligated kidney,Na+/Ca2+
exchanger mRNA level is lower than that in WKY rats and normal
kidney. In ischemic heart induced by isoprenaline,this mRNA level
increased. |
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| Keywords: | Na+/Ca2+ exchanger gene Spontaneously hypertensive rat Ischemic heart and kidney |
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